Phytates as a natural source for health promotion: A critical evaluation of clinical trials

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dc.authoridCalina, Daniela/0000-0002-1523-9116
dc.authoridParedes-Osses, Esteban/0000-0002-9432-4203
dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridCardoso, Susana M./0000-0002-7882-737X
dc.authoridSilva Reis, Rita Maria/0000-0002-2463-5655
dc.contributor.authorPires, Sonia M. G.
dc.contributor.authorReis, Rita Silva
dc.contributor.authorCardoso, Susana M.
dc.contributor.authorPezzani, Raffaele
dc.contributor.authorParedes-Osses, Esteban
dc.contributor.authorSeilkhan, Ainur
dc.contributor.authorYdyrys, Alibek
dc.date.accessioned2024-10-26T18:11:38Z
dc.date.available2024-10-26T18:11:38Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPhytates are a type of organophosphorus compound produced in terrestrial ecosystems by plants. In plant feeds, phytic acid and its salt form, phytate, account for 60%-80% of total phosphorus. Because phytate is a polyanionic molecule, it can chelate positively charged cations such as calcium, iron, and zinc. Due to its prevalence in vegetal tissues and the fact that people consume plants, phytate was first considered a potential health benefit. This updated review aims to summarize the current data on the results of clinical trials of phytates on human health, highlighting both beneficial and undesirable effects. To obtain these updated data, published papers in electronic databases such as PubMed/MedLine, TRIP database, Wiley, Google Scholar, Baidu, and Scopus were searched. Study results have shown that phytate can have beneficial health effects such as antioxidant, anticancer potential and reduction of pathological calcifications in blood vessels and organs; but also, negative effects by reducing the absorption of minerals important for maintaining the homeostasis of the human body. According to these recent results derived from recent clinical studies, phytates may be a potential natural source for health benefits. To improve clinical efficacy and human health benefits, further dose-response studies are needed to determine effective therapeutic doses and potential interactions with conventional drugs.
dc.description.sponsorship[ACE210012]
dc.description.sponsorshipMM wants to thank ANID CENTROS BASALES ACE210012.
dc.identifier.doi10.3389/fchem.2023.1174109
dc.identifier.issn2296-2646
dc.identifier.pmid37123871
dc.identifier.scopus2-s2.0-85159838134
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fchem.2023.1174109
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30768
dc.identifier.volume11
dc.identifier.wosWOS:000979135500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectphytate
dc.subjectnutrients
dc.subjecthealth benefits
dc.subjectclinical trials
dc.subjectorganophosphorus compound
dc.titlePhytates as a natural source for health promotion: A critical evaluation of clinical trials
dc.typeReview Article

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