Antiproliferative effects of 5FU-AgNPs on different breast cancer cells

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dc.authoridkariper, ishak afsin/0000-0001-9127-301X
dc.authoridhepokur, ceylan/0000-0001-6397-1291
dc.authoridUstundag, Hilal/0000-0003-3140-0755
dc.contributor.authorDanisman-Kalindemirtas, Ferdane
dc.contributor.authorKariper, I. Afsin
dc.contributor.authorUstundag, Hilal
dc.contributor.authorOzsoy, Ceylan
dc.contributor.authorErdem-Kuruca, Serap
dc.date.accessioned2024-10-26T18:09:53Z
dc.date.available2024-10-26T18:09:53Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBreast cancer is a leading cause of cancer-related deaths in women, and researchers are seeking more effective treatments. Nanotechnology offers a promising approach by creating nanocarriers to reduce the side effects of cancer drugs. This study synthesized AgNPs-5FU nanoparticles by binding the anticancer drug 5-fluorouracil (5FU) to a silver nanocarrier, significantly increasing 5FU's cytotoxicity. Characterization using DLS, SEM, UV-Vis, and FTIR confirmed the nanoparticles' properties, with a size of 18-28 nm and a PDI of 0.598. The release of 5FU from AgNPs-5FU was about 70%, demonstrating sustained and controlled release. Cytotoxicity results showed that AgNPs-5FU had an IC50 value of 23.006 in MCF-7 cells and 10.41 in 4T1 cells, making it 2.14 and 4.64 times more effective than free 5FU, respectively. Low cytotoxicity was observed in HUVEC cells. This study indicates that AgNPs-5FU has significantly higher potential activity against cancer cells compared to free 5FU.
dc.identifier.doi10.1080/16583655.2024.2354573
dc.identifier.issn1658-3655
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85195114366
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1080/16583655.2024.2354573
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30321
dc.identifier.volume18
dc.identifier.wosWOS:001235495400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Taibah University For Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSilver nanoparticles
dc.subjectcytotoxicity
dc.subject5FU
dc.subjectdifferent breast cancer cells
dc.titleAntiproliferative effects of 5FU-AgNPs on different breast cancer cells
dc.typeArticle

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