Evaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic fever

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dc.authoridOflaz, Mehmet Burhan -- 0000-0003-1515-4654en_US
dc.contributor.authorDeveci, Koksal
dc.contributor.authorOflaz, Mehmet Burhan
dc.contributor.authorSancakdar, Enver
dc.contributor.authorUysal, Elif Bilge
dc.contributor.authorGuven, Ahmet Sami
dc.contributor.authorKaya, Ali
dc.contributor.authorAlkan, Filiz
dc.contributor.authorCevit, Omer
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:57:08Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:57:08Z
dc.date.issued2014
dc.department[Deveci, Koksal -- Sancakdar, Enver -- Alkan, Filiz] Cumhuriyet Univ, Fac Med, Dept Clin Biochem, TR-58140 Sivas, Turkey -- [Oflaz, Mehmet Burhan -- Guven, Ahmet Sami -- Kaya, Ali -- Cevit, Omer] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Uysal, Elif Bilge] Cumhuriyet Univ, Fac Med, Dept Clin Microbiol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractWe aimed to assess the association between serum levels of soluble IL-2 receptor (sIL-2r) and endothelin-1 and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Fifty-two patients under 18 years of age with a laboratory-confirmed diagnosis of CCHF and 38 healthy controls were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and non-severe group). The sIL-2r and endothelin-1 levels were observed to be significantly higher in patients with severe CCHF compared with those with non-severe CCHF and the control group (p < 0.05). In addition, those with non-severe CCHF were also found to have a significantly higher sIL-2r level relative to the control group (p < 0.001). Although there was a positive correlation between sIL-2r and endothelin-1 levels, serum levels of both sIL-2r and endothelin-1 were negatively correlated with the platelets count. In children with CCHF, serum levels of sIL-2r and endothelin-1 were increased, and this increase is related to the severity of the disease. In this study, we concluded through prognosis that serum levels of sIL-2r and endothelin-1 might be related, and that hemophagocytic lymphohistiocytosis and endothelial injury might contribute to a pathogenesis of the disease.en_US
dc.description.sponsorshipResearch Foundation Council of Cumhuriyet University [T-539]en_US
dc.description.sponsorshipThe Research Foundation Council of Cumhuriyet University partly supported this study (Project No. T-539).en_US
dc.identifier.doi10.1111/apm.12209en_US
dc.identifier.endpage647en_US
dc.identifier.issn0903-4641
dc.identifier.issn1600-0463
dc.identifier.issue7en_US
dc.identifier.pmid24320760en_US
dc.identifier.scopus2-s2.0-84902836045en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage643en_US
dc.identifier.urihttps://dx.doi.org/10.1111/apm.12209
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8230
dc.identifier.volume122en_US
dc.identifier.wosWOS:000338030400010en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofAPMISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectsoluble IL-2ren_US
dc.subjectendothelin-1en_US
dc.titleEvaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic feveren_US
dc.typeArticleen_US

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