Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant

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dc.contributor.authorYıldırım, Ayşenur
dc.contributor.authorAtaş, Ahmet Duran
dc.date.accessioned2024-10-26T17:51:29Z
dc.date.available2024-10-26T17:51:29Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Toxoplasma gondii is the causative agent of toxoplasmosis and is a parasite of high medical importance with a wide host variety. Bacterial, viral, and parasitic infections during pregnancy may predispose women to pregnancy complications. Preeclampsia of unknown etiology causes special conditions such as systemic vascular endothelial damage due to insufficient trophoblastic invasion and abnormal placentation. There are data of an association between various maternal infections and preeclampsia/ eclampsias. The aim of the study was to compare and analyze the relationship between the presence of anti-Toxoplasma IgM and anti-Toxoplasma IgG antibodies in pregnant women with pre-eclampsia and in normotensive healthy pregnant women who were in the control group. Methods: In this study, 176 pregnant women who applied to our hospital between January 2019 and December 2020 were included. 88 (50%) of the pregnant women had pre-eclampsia and 88 (50%) were normotensive. The presence of anti-Toxoplasma IgM and IgG antibodies in blood taken from pregnant women with pre-eclampsia and control group was investigated using ELISA. Results: Because of the study, both groups were found to be seronegative in terms of anti-Toxoplasma IgM by ELISA. Anti-Toxoplasma IgG was found to be seropositive in 24 (27.3%) pregnant women with pre-eclampsia and 18 (20.5%) normotensive pregnant women. There was no statistically significant difference between the two groups in terms of anti-Toxoplasma IgM and anti-Toxoplasma IgG seropositivity (X2=0.289, p>0.05) (p<0.05). Conclusion: Because of the study, no statistically significant difference was found between pregnant women with pre-eclampsia and those with toxoplasmosis. It was thought that further studies should be conducted to discuss the hormonal, vascular, etc. factors occurring in the pathogenesis of preeclampsia of T. gondii effect of preparing the ground for the changes and to reveal the existence of a possible relationship between pre-eclampsia and T. gondii seropositivity. © Telif hakkı 2023 Türkiye Parazitoloji Derneği.
dc.description.sponsorshipCumhuriyet Üniversitesi Bilimsel Araştırma Projeleri Komisyonu tarafından desteklenmiştir, (T-865)
dc.identifier.doi10.4274/tpd.galenos.2023.80664
dc.identifier.endpage213
dc.identifier.issn1300-6320
dc.identifier.issue4
dc.identifier.pmid38149440
dc.identifier.scopus2-s2.0-85180819918
dc.identifier.scopusqualityQ4
dc.identifier.startpage209
dc.identifier.trdizinid1263170
dc.identifier.urihttps://doi.org/10.4274/tpd.galenos.2023.80664
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263170
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26260
dc.identifier.volume47
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isotr
dc.publisherGalenos Publishing House
dc.relation.ispartofTurkiye Parazitoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectELISA; immunoglobulin; preeclampsia; Toxoplasma gondii
dc.titleInvestigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant
dc.title.alternativePreeklampsili Gebelerde Toxoplasma gondii Seroprevalansının Araştırılması
dc.typeArticle

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