The effects of chrysin on lipopolysaccharide-induced sepsis in rats

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dc.authoridTEKELI, MUHAMMET YASIN/0000-0002-9382-9605
dc.contributor.authorKoc, Feride
dc.contributor.authorTekeli, Muhammet Yasin
dc.contributor.authorKanbur, Murat
dc.contributor.authorKarayigit, Mehmet onder
dc.contributor.authorLiman, Bilal Cem
dc.date.accessioned2024-10-26T18:05:27Z
dc.date.available2024-10-26T18:05:27Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractChrysin (CR) is a flavone found in propolis and many plants. Lipopolysaccharide (LPS) is a component of the cell wall of gram-negative bacteria that causes sepsis. The purpose of this study was to investigate the effects of CR on LPS-induced sepsis in rats. LPS intraperitoneal and a single dose and CR were given orally for 10 days. Rats were sacrificed, blood samples were taken, liver, lung, and kidney tissues were dissected, homogenized, and histopathological analysis was carried out. When CR groups compared to sepsis group, CR significantly decreased the serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin-1 beta (IL-1 beta), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and levels of malondialdehyde (MDA) in tissues. CR also increased the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in tissues. Histopathological findings were consistent with biochemical findings. Conclusion, CR could reduce the oxidative stress markers and cytokines in sepsis. Practical applications Our approach is to determine the antioxidant and anti-inflammatory effects of chrysin, known as a flavolonoid, which are found in many plants and foods such as honey and propolis. In this study, experimental sepsis model was created using LPS. According to the results of the study, CR can attribute to the ameliorating of oxidative damage in tissues (lung, liver, and kidney) and it can suppress the sepsis-associated acute tissue injury via reduction of inflammation in rats. Even, CR can be used as a pharmacological agent in inflammatory diseases caused by other sources and in many cases causing oxidation.
dc.description.sponsorshipScientific Research Council of Erciyes University, Kayseri, Turkey [TSA-2017-7128]
dc.description.sponsorshipThis study was supported by the Scientific Research Council of Erciyes University, Kayseri, Turkey (Project no: TSA-2017-7128).
dc.identifier.doi10.1111/jfbc.13359
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue9
dc.identifier.pmid32614079
dc.identifier.scopus2-s2.0-85087295655
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/jfbc.13359
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28997
dc.identifier.volume44
dc.identifier.wosWOS:000544721100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Food Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantioxidant
dc.subjectchrysin
dc.subjectcytokine
dc.subjectlipopolysaccharide
dc.subjectsepsis
dc.titleThe effects of chrysin on lipopolysaccharide-induced sepsis in rats
dc.typeArticle

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