The Effects of Erzincan Grape (Vitis vinifera spp., Cimin) and Benzothiazol on a Coenorhabditis elegans Organism Model

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dc.contributor.authorOzpinar, Hulya
dc.contributor.authorOzpinar, Necati
dc.contributor.authorKarakus, Savas
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:41:27Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:41:27Z
dc.date.issued2017
dc.department[Ozpinar, Hulya] Cumhurlyet Univ, Fac Pharm, Dept Pharmaceut Bot, Sivas, Turkey -- [Ozpinar, Necati] Cumhurlyet Univ, Fac Med, Dept Parasitol, Sivas, Turkey -- [Karakus, Savas] Cumhuriyet Univ, Fac Med, Dept Obstet & Gynecol, Sivas, Turkeyen_US
dc.description.abstractBackground: Grapes and their products are known to have been used for the treatment of diseases throughout history. Objective: It was aimed to investigate the effects of Erzincan Cimin grapes on an organism model of Caenorhabditis elegans N2 wild type and C. elegans BS913 strains with gonad cancer. Materials and Methods: The effects of methanol extracts of the skin and seeds of Erzincan Cimin grapes were examined separately on C. elegans N2 wild type and an effect was determined on lifespan. By applying GS-MS analysis, a potential agent substance was determined in the skin and seed methanol extracts. This substance was purchased and the effects of this substance were investigated on lifespan and fertility in C. elegans BS913 strains with gonad cancer. In addition, the effects on young subjects exposed to this agent substance in L1 form were investigated. Results: Grape seed and skin methanol extract was observed to prolong the lifespan most at a dose of 10 mg/100 mL. Lifespan was determined to be at a maximum in a gonad cancer organism model with benzothiazol at a dose of 50 ppm. At the same dose, positive effects were determined on the fertility of strains with cancer. When the effects of benzothiazol were examined on young Li forms, an evident retardation of growth was determined at doses of 10, 50, and 100 ppm. Conclusion: Owing to anti-carcinogenic effects of benzothiazol and benzothiazol-derived substances, they can be considered as agent substances in academic studies related to cancer.en_US
dc.identifier.doi10.4103/0973-1296.210164en_US
dc.identifier.endpageS384en_US
dc.identifier.issn0973-1296
dc.identifier.issn0976-4062
dc.identifier.issue50en_US
dc.identifier.pmid28808410en_US
dc.identifier.scopus2-s2.0-85032906600en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpageS380en_US
dc.identifier.urihttps://dx.doi.org/10.4103/0973-1296.210164
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6806
dc.identifier.volume13en_US
dc.identifier.wosWOS:000413704300036en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTDen_US
dc.relation.ispartofPHARMACOGNOSY MAGAZINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitis viniferaen_US
dc.subjectCiminen_US
dc.subjectBenzothiazolen_US
dc.subjectCaenorhabditisen_US
dc.subjectelegansen_US
dc.subjectLifespanen_US
dc.subjectAnti-carcinogenic effectsen_US
dc.titleThe Effects of Erzincan Grape (Vitis vinifera spp., Cimin) and Benzothiazol on a Coenorhabditis elegans Organism Modelen_US
dc.typeArticleen_US

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