The effect of octreotide, an analog of somatostatin, on bleomycin-induced interstitial pulmonary fibrosis in rats

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dc.authoridTug, Esra -- 0000-0002-2408-5294en_US
dc.contributor.authorTug, Tuncer
dc.contributor.authorKara, Haki
dc.contributor.authorKaraoglu, Aziz
dc.contributor.authorKaratas, Fikret
dc.contributor.authorTurgut, Nergiz Hacer
dc.contributor.authorAyan, Erhan
dc.contributor.authorBoran, Cetin
dc.contributor.authorTug, Esra
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:00:09Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:00:09Z
dc.date.issued2013
dc.department[Tug, Tuncer] Abant Izzet Baysal Univ, Fac Med, Dept Chest Dis, Bolu, Turkey -- [Kara, Haki -- Turgut, Nergiz Hacer] Cumhuriyet Univ, Dept Pharmacol & Toxicol, Fac Vet Med, TR-58140 Sivas, Turkey -- [Karaoglu, Aziz] Firat Univ, Fac Med, Dept Oncol, TR-23169 Elazig, Turkey -- [Karatas, Fikret] Firat Univ, Dept Chem, Fac Sci, TR-23169 Elazig, Turkey -- [Ayan, Erhan] Mersin Univ, Fac Med, Dept Chest Surg, Mersin, Turkey -- [Boran, Cetin] Abant Izzet Baysal Univ, Fac Med, Dept Pathol, Bolu, Turkey -- [Tug, Esra] Abant Izzet Baysal Univ, Fac Med, Dept Genet, Bolu, Turkeyen_US
dc.description.abstractIn this study, octreotide (OCT), a synthetic sonnatostatin analog, was tested for its beneficial effects in the prevention of interstitial pulmonary fibrosis (IPF) induced by bleomycin (BLM) in rats by histological examination and by evaluating tissue OH-proline levels. Thirty male Wistar rats were divided randomly into three groups: group I: intratracheal (i.t.) BLM (7.5 mg/kg, single dose) + saline solution [0.9% NaCl, subcutaneously (s.c.), once-daily for 7 days]; group II: i.t. BLM (7.5 mg/kg, single dose) + OCT acetate (82.5 mu g/kg, s.c., once-daily for 7 days); and the control group. At the end of the 7 days, lung tissues were excised and examined by histopathological methods. Levels of tissue hydroxyproline (OH-proline) were determined. BLM administration resulted in prominent histopathologic findings, such as diffuse alveolar damage and interstitial pulmonary fibrosis, as well as a significant increase in OH-proline level, as compared to controls. OCT application explicitly attenuated the histopathologic changes to a significant extent. OCT decreased paranchymal fibrosis and structural deformities in BLM-induced lung fibrosis. These results suggest that OCT administration to rats with BLM-induced IPF has a protective effect. Further studies are necessary to reveal the molecular mechanism(s) of OCT-induced protective effect.en_US
dc.identifier.doi10.3109/01480545.2012.710618en_US
dc.identifier.endpage186en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue2en_US
dc.identifier.pmid22946449en_US
dc.identifier.scopus2-s2.0-84871207724en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage181en_US
dc.identifier.urihttps://dx.doi.org/10.3109/01480545.2012.710618
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8749
dc.identifier.volume36en_US
dc.identifier.wosWOS:000316979600007en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofDRUG AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBleomycinen_US
dc.subjectpulmonary fibrosisen_US
dc.subjectoctreotideen_US
dc.subjectratsen_US
dc.titleThe effect of octreotide, an analog of somatostatin, on bleomycin-induced interstitial pulmonary fibrosis in ratsen_US
dc.typeArticleen_US

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