Increased Irisin Concentrations in Patients with Crimean-Congo Hemorrhagic Fever

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dc.contributor.authorBuyuktuna, Seyit Ali
dc.contributor.authorDogan, Halef Okan
dc.contributor.authorBakir, Deniz
dc.contributor.authorErsan, Serpil
dc.contributor.authorKoc, Derya
dc.contributor.authorBakir, Sevtap
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:40:28Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:40:28Z
dc.date.issued2017
dc.department[Buyuktuna, Seyit Ali] Univ Cumhuriyet, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Dogan, Halef Okan -- Bakir, Deniz -- Ersan, Serpil -- Koc, Derya -- Bakir, Sevtap] Univ Cumhuriyet, Fac Med, Dept Biochem, Sivas, Turkeyen_US
dc.description.abstractCrimean -Congo Hemorrhagic Fever (CCHF) is a life-threatening viral infection. The pathogenesis of the disease is not well understood. The aim of this study was to determine the change in irisin concentrations in patients with CCHF. The study included a total of 30 patients with CCHF and 30 control participants. Irisin concentrations were determined using a commercial ELISA kit. Median irisin concentrations were 9.03 (5.81-12.22) mu g/mL and 4.2 (3.39-7.62) mu g/mL, respectively, in each group. There was no correlation between irisin and disease severity. Any correlations between irisin, and lactate dehydrogenase (LDH), international normalization ratio (INR), Alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelets, activated partial thromboplastin time (aPTT), D-dimer and hemoglobin, were also investigated. There were statistically significant positive correlations between the values of irisin, and platelet (p = 0.005, r: 0.369), ALT (p = 0.049, r: 0.261), INR (p = 0.006, r: 0.359) and aPTT values (p = 0.002, r: 0.405). A negative correlation was also found between the values of irisin and LDH (p = 0.008, r: 0.348). No correlations were determined between the values of irisin, and AST, hemoglobin and D-dimer. These results suggest that irisin may have a role in CCHF.en_US
dc.identifier.doi10.7883/yoken.JJID.2016.432en_US
dc.identifier.endpage478en_US
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue5en_US
dc.identifier.pmid28250262en_US
dc.identifier.scopus2-s2.0-85030086073en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage475en_US
dc.identifier.urihttps://dx.doi.org/10.7883/yoken.JJID.2016.432
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6684
dc.identifier.volume70en_US
dc.identifier.wosWOS:000412715600001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATL INST INFECTIOUS DISEASESen_US
dc.relation.ispartofJAPANESE JOURNAL OF INFECTIOUS DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleIncreased Irisin Concentrations in Patients with Crimean-Congo Hemorrhagic Feveren_US
dc.typeArticleen_US

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