Achillea goniocephala Extract Loaded into Nanochitosan: In Vitro Cytotoxic and Antioxidant Activity

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dc.authoridErmanoglu, Mizgin/0000-0003-3146-1988
dc.authoridARABACI, Turan/0000-0003-3869-4557
dc.contributor.authorTaskin, Duygu
dc.contributor.authorDogan, Murat
dc.contributor.authorErmanoglu, Mizgin
dc.contributor.authorArabaci, Turan
dc.date.accessioned2024-10-26T18:00:22Z
dc.date.available2024-10-26T18:00:22Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: The present study aimed to prepare Achillea goniocephala chloroform extract and evaluate antioxidant and cytotoxic effects. Then, the nanoparticles (NPs) were synthesized on the most efficient extracts and the biological activities of the free forms of the extracts were compared with the NPs forms. Methods: Antioxidant capacities of 14 extracts (A-N) prepared using column chromatography were determined by FRAP, DPPH and CUPRAC methods. Again, the cytotoxic activities of all fractions were evaluated on MCF-7 and HT-29 cell lines using the XTT cell viability assay. Chitosantripolyphosphate (TPP) NPs of the extracts with the most active biological properties were formed using the ionic gelation method. Results: The particle size of the NPs synthesized from the two most efficient extracts was found to be between 274.12 and 296.25 nm. The extract-encapsulation and loading-efficiency of the most active NPs were found 77.6 +/- 0.04% and 7.76 +/- 0.01% for the F extract and 10.2 +/- 0.02 and 1.39 +/- 0.07% for the H extract, respectively. Conclusions: While antioxidant activity results of chitosan NPs were close to unencapsulated extracts, cytotoxic activity results were found to be better than unencapsulated extracts. Based on these results, it is thought that it would be more effective to use the encapsulated forms of A. goniocephala instead of the raw extract of the plant in the treatment.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBTAK) [116S509]
dc.description.sponsorshipWe would like to thank the Scientific and Technological Research Council of Turkey (TUBTAK) for thefinancial support of this research (Project No: 116S509) and Serkan Kostekci for help during the field studies.
dc.identifier.doi10.33808/clinexphealthsci.972180
dc.identifier.endpage666
dc.identifier.issn2459-1459
dc.identifier.issue4
dc.identifier.startpage659
dc.identifier.trdizinid482365
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.972180
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/482365
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27660
dc.identifier.volume11
dc.identifier.wosWOS:000743967900007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ, Inst Health Sciences
dc.relation.ispartofClinical and Experimental Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNanoparticles
dc.subjectCytotoxicity
dc.subjectAntioxidant
dc.subjectChitosan
dc.subjectEncapsulation efficiency
dc.titleAchillea goniocephala Extract Loaded into Nanochitosan: In Vitro Cytotoxic and Antioxidant Activity
dc.typeArticle

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