Effect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factors

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dc.contributor.authorGokcen, Kaan
dc.contributor.authorKilicarslan, Hakan
dc.contributor.authorCoskun, Burhan
dc.contributor.authorErsoy, Alparslan
dc.contributor.authorKaygisiz, Onur
dc.contributor.authorKordan, Yakup
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:46:54Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:46:54Z
dc.date.issued2016
dc.department[Gokcen, Kaan] Cumhuriyet Univ, Dept Urol, Sivas, Turkey -- [Kilicarslan, Hakan -- Coskun, Burhan -- Kaygisiz, Onur -- Kordan, Yakup] Uludag Univ, Dept Urol, Bursa, Turkey -- [Ersoy, Alparslan] Uludag Univ, Dept Nephrol, Bursa, Turkeyen_US
dc.description.abstractIntroduction: Hormonal, neurogenic, vasculogenic, and psychogenic impairments, as well as endothelial dysfunction may play a role in erectile dysfunction (ED) in patients with chronic kidney disease (CKD). Asymmetrical dimethylarginine (ADMA) is an inhibitor of nitric oxide, which is the key element of ED. ADMA levels are increased in CKD. We aimed to evaluate the effect of serum ADMA, prolactin, testosterone, and hemoglobin levels on erectile function of patients with CKD and control subjects. Methods: A total of 42 men with CKD and 25 age-matched controls were enrolled. The patients with CKD were categorized into group 1 and group 2 based on whether they had ED according to their response to International Index of Erectile Function questionnaire (IIEF-EFD). Group 3 was a control group. Serum ADMA, total testosterone prolactin, and hemoglobin levels of the patients were evaluated. Results: Serum ADMA, testosterone, and hemoglobin levels were similar between group 1 and 2, serum prolactin level was significantly high in group 1 than in group 2 or 3 (control group). There was no correlation between ADMA levels and IIEF-EFD scores of patients with CKD. Conclusions: The results of this study suggest serum ADMA level is not related with ED in patients with CKD. Also, low testosterone and hemoglobin levels were not significant factors. High levels of serum prolactin are related with ED in patients with CKD.en_US
dc.identifier.doi10.5489/cuaj.3170en_US
dc.identifier.endpageE45en_US
dc.identifier.issn1911-6470
dc.identifier.issn1920-1214
dc.identifier.issue01.Feben_US
dc.identifier.pmid26858787en_US
dc.identifier.scopus2-s2.0-84954531003en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpageE41en_US
dc.identifier.urihttps://dx.doi.org/10.5489/cuaj.3170
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7594
dc.identifier.volume10en_US
dc.identifier.wosWOS:000373178500009en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCANADIAN UROLOGICAL ASSOCIATIONen_US
dc.relation.ispartofCUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factorsen_US
dc.typeArticleen_US

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