STOX1 gene Y153H polymorphism is associated with early-onset preeclampsia in Turkish population

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dc.authoridBildirici, Aslihan Esra/0000-0003-2438-3723
dc.contributor.authorPinarbasi, Ergun
dc.contributor.authorCekin, Nilgun
dc.contributor.authorBildirici, Aslihan Esra
dc.contributor.authorAkin, Seyda
dc.contributor.authorYanik, Ali
dc.date.accessioned2024-10-26T18:03:55Z
dc.date.available2024-10-26T18:03:55Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPreeclampsia (PE) is a disease of pregnancy that causes of maternal and prenatal morbidity worldwide. Studies indicate that variations in STOX1 gene may be a direct risk factor to PE but controversial results regarding the relationship of Y153H variation in the second exon of STOX1 gene with PE have been ongoing since 2005. The aim of this study was to identify if there is any correlation between Y153H polymorphisms and PE in Turkish preeclampsia patients. We performed polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) analysis in 500 pregnant women, of whom 373 pregnant women with early onset PE (EOPE) and 500 normal pregnant women. The relationship between STOX1 Y153H polymorphism and EOPE/LOPE was evaluated by statistical analysis. We found that STOX1 Y153H polymorphism is a risk factor for EOPE (p = 0.03). The odds ratio was 1,45 (CI 95% = 1,03-2,05). No relationship between STOX1 Y153H polymorphisms and LOPE (p = 0.13) was found. STOX1 gene Y153H polymorphism is associated with the risk of early onset of pre-eclampsia in a Turkish population. The results provide further evidence of the role of STOX1 in the pathophysiology of this disease.
dc.identifier.doi10.1016/j.gene.2020.144894
dc.identifier.issn0378-1119
dc.identifier.issn1879-0038
dc.identifier.pmid32534058
dc.identifier.scopus2-s2.0-85088040268
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.gene.2020.144894
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28659
dc.identifier.volume754
dc.identifier.wosWOS:000551878600035
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofGene
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPreeclampsia
dc.subjectSTOX1
dc.subjectY153H polymorphism
dc.subjectTurkish population
dc.titleSTOX1 gene Y153H polymorphism is associated with early-onset preeclampsia in Turkish population
dc.typeArticle

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