Atrial natriuretic peptide predicts impaired atrial remodeling and occurrence of late postoperative atrial fibrillation after surgery for symptomatic aortic stenosis

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dc.authoridYILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628en_US
dc.contributor.authorYimaz, Mehmet Birhan
dc.contributor.authorErbay, Ali Riza
dc.contributor.authorBalci, Mustafa
dc.contributor.authorGuray, Yesim
dc.contributor.authorCihan, Gokhan
dc.contributor.authorGuray, Umit
dc.contributor.authorKisacik, Halil L.
dc.contributor.authorKorkmaz, Sule
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:21:54Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:21:54Z
dc.date.issued2006
dc.departmentCumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- Yuksek Ihtisas Educ & Res Hosp, Cardiol Clin, Ankara, Turkeyen_US
dc.description.abstractBackground. Aortic stenosis (AS) and atrial fibrillation (AF) are commonly encountered in clinical practice. Natriuretic peptides (NP) are endogenous cardiac hormones, which have been shown to increase in patients with heart failure, and valvular or congenital heart disease. We aimed to determine the association between atrial NP (ANP) and late postoperative AF after surgery for AS along with temporal changes in plasma ANP levels and left atrial (LA) volumes. Methods: 22 patients (16 males/6 females, mean age: 61 years) with symptomatic AS and 8 healthy volunteers (5 males/3 females) were enrolled into our study. All the patients studied underwent transthoracic echocardiography, which was repeated during the follow-up. N-terminal ANP (N-ANP) was studied initially and at the 2-month follow-up. Postoperatively, the patients were followed up for 12 months for AF attacks. Results: Patients with AS had significantly higher levels of N-ANP, left ventricular (LV) end-diastolic pressure, E/A ratio, LV mass and LA volumes compared to the controls. Patients with postoperative AF attacks were significantly older, had higher N-ANP levels and LV end-diastolic pressure in addition to higher LA volumes and longer symptom duration compared to patients without AF. Age at the time of operation (p = 0.011) and N-ANP at the 2nd month (p = 0.047) were found to be independent predictors for late AF attacks during follow-up in regression analysis. Besides, N-ANP (p < 0.001) at the 2-month follow-up independently predicted impaired LA remodeling. Conclusion:ANP might be an important factor to identify AS patients at risk for late postoperative AF attacks. Copyright (c) 2006 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000091641en_US
dc.identifier.endpage212en_US
dc.identifier.issn0008-6312
dc.identifier.issn1421-9751
dc.identifier.issue4en_US
dc.identifier.pmid16498244en_US
dc.identifier.scopus2-s2.0-33646683818en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage207en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000091641
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10886
dc.identifier.volume105en_US
dc.identifier.wosWOS:000237777700003en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofCARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatrial natriuretic peptideen_US
dc.subjectatrial fibrillationen_US
dc.subjectcardioconversionen_US
dc.subjectvalvuloplastyen_US
dc.subjectstenosisen_US
dc.titleAtrial natriuretic peptide predicts impaired atrial remodeling and occurrence of late postoperative atrial fibrillation after surgery for symptomatic aortic stenosisen_US
dc.typeArticleen_US

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