Protective effects of lamotrigine and vitamin B12 on pentylenetetrazole-induced epileptogenesis in rats

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dc.authoridTaskiran, Ahmet Sevki/0000-0002-5810-8415
dc.authoridKARABULUT, SEBAHATTIN/0000-0002-3261-4125
dc.contributor.authorFiliz, Ahmet Kemal
dc.contributor.authorGumus, Erkan
dc.contributor.authorKarabulut, Sebahattin
dc.contributor.authorTastemur, Yasar
dc.contributor.authorTaskiran, Ahmet Sevki
dc.date.accessioned2024-10-26T18:07:38Z
dc.date.available2024-10-26T18:07:38Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractEpileptogenesis is a process that includes molecular and cellular events that foster the establishment of hyperexcitable neuronal networks in the brain. Pentylenetetrazole (PTZ)-induced kindling model in rodents has added new information to the knowledge about the pathogenesis of epilepsy and potential targets of novel antiepileptic agents. Evidence from animal and human studies suggests that oxidative and inflammatory events may play important roles in the initiation and maintaining seizure activities. Vitamin B12 has beneficial effects on the nervous system and presents pleiotropic effects with antioxidant and anti-inflammatory aspects. In the present study, we aimed to test the hypothesis that vitamin B12 and their combination with lamotrigine prevents behavioral deficits, hippocampal damage, oxidation, and proinflammatory state during epileptogenesis. Male rats were subjected to PTZ-induced epileptogenesis and pretreated with vitamin B12 (50 mu g/kg) or Lamotrigine (LTG) (25 mg/kg) or B12 (50 mu g/kg) + LTG (25 mg/kg). Vitamin B12 and its combination with LTG suppressed epileptogenesis and improved the performance of rats in the passive avoidance test. In addition, Vitamin B12 and its combination with LTG decreased levels of total oxidative status (TOS), oxidative stress index (OSI), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and increased total antioxidant status (TAS) levels in the hippocampus and cerebral cortex. Furthermore, it reduced hippocampal neuronal damage. Current findings support the beneficial actions of vitamin B12 due to its antioxidative and anti-inflammatory properties during the course of disease. (C) 2021 Elsevier Inc. All rights reserved.
dc.description.sponsorshipSivas Cumhuriyet University Project Service CUBAP [T-759]
dc.description.sponsorshipThe work was supported by grants from Sivas Cumhuriyet University Project Service CUBAP (T-759).
dc.identifier.doi10.1016/j.yebeh.2021.107915
dc.identifier.issn1525-5050
dc.identifier.issn1525-5069
dc.identifier.pmid33743341
dc.identifier.scopus2-s2.0-85102638747
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.yebeh.2021.107915
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29607
dc.identifier.volume118
dc.identifier.wosWOS:000647685700045
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEpilepsy & Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpileptogenesis
dc.subjectPentylenetetrazole
dc.subjectVitamin B12
dc.subjectOxidative stress
dc.subjectNeuroinflammation
dc.subjectNeuronal damage
dc.titleProtective effects of lamotrigine and vitamin B12 on pentylenetetrazole-induced epileptogenesis in rats
dc.typeArticle

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