Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease

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dc.authoridSari, Ismail -- 0000-0003-3732-2102en_US
dc.contributor.authorYilmaz, Meral
dc.contributor.authorSari, Ismail
dc.contributor.authorBagci, Binnur
dc.contributor.authorGumus, Erkan
dc.contributor.authorOzdemir, Ozturk
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:56:10Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:56:10Z
dc.date.issued2015
dc.department[Yilmaz, Meral] Cumhuriyet Univ, Sch Med, Dept Res Ctr, Sivas, Turkey -- [Sari, Ismail] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth, Dept Nutr & Diet, Sivas, Turkey -- [Gumus, Erkan] Cumhuriyet Univ, Sch Med, Dept Histol & Embryol, Sivas, Turkey -- [Ozdemir, Ozturk] Canakkale Onsekiz Mart Univ, Sch Med, Dept Med Genet, Canakkale, Turkeyen_US
dc.description.abstractIntroduction. It has been shown that gene polymorphisms influence the development and progression of chronic kidney disease (CKD). Many studies have indicated that aldosterone synthase CYP11B2 gene polymorphism (-344C>T) influences the aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. We aimed to investigate whether there is an effect of CYP11B2 -344C>T polymorphism on the development of CKD in a Turkish population. Material and Methods. A total of 240 patients with stage 5 CKD and 240 age- and sex-matched healthy individuals were included in the study. Genotyping of CYP11B2 gene -344 T>C promoter polymorphism was carried out using polymerase chain reaction and restriction fragment length polymorphism methods. Results. No significant differences were found in the genotype distribution of CYP11B2 -344 C>T polymorphism between the patients and controls; however, -344 C>T polymorphism was significantly more frequent among the CKD patients with diabetes mellitus as compared to those with it (P = .02). Diabetic CKD patients with TC genotype had a 2-fold increased risk for development of the disease than the CKD patients without diabetes mellitus (odds ratio, 2.21; 95% confidence interval, 1.04 to 4.67). Conclusions. Our study suggests that the CYP11B2 gene -344 C>T polymorphism may have an effect on the development of CKD in diabetic patients.en_US
dc.identifier.endpage214en_US
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue3en_US
dc.identifier.pmid25957425en_US
dc.identifier.scopus2-s2.0-84928989713en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage209en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7867
dc.identifier.volume9en_US
dc.identifier.wosWOS:000355275200007en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIRANIAN SOC NEPHROLGYen_US
dc.relation.ispartofIRANIAN JOURNAL OF KIDNEY DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaldosterone synthase geneen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectgene polymorphismen_US
dc.titleAldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Diseaseen_US
dc.typeArticleen_US

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