The Safety and Efficacy of Etanercept on Cardiac Functions and Lipid Profile in Patients With Active Rheumatoid Arthritis

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dc.contributor.authorSenel, Soner
dc.contributor.authorCobankara, Veli
dc.contributor.authorTaskoylu, Ozgur
dc.contributor.authorKarasu, Ugur
dc.contributor.authorKarapinar, Hekim
dc.contributor.authorErdis, Eda
dc.contributor.authorEvrengul, Harun
dc.contributor.authorKaya, Mehmet Gungor
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:04:40Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:04:40Z
dc.date.issued2012
dc.department[Senel, Soner] Cumhuriyet Univ, Sch Med, Dept Rheumatol, Div Rheumatol, TR-58140 Sivas, Turkey -- [Senel, Soner -- Cobankara, Veli -- Karasu, Ugur] Pamukkale Univ, Sch Med, Div Rheumatol, Denizli, Turkey -- [Taskoylu, Ozgur -- Evrengul, Harun] Pamukkale Univ, Sch Med, Div Cardiol, Denizli, Turkey -- [Karapinar, Hekim] Cumhuriyet Univ, Sch Med, Div Cardiol, TR-58140 Sivas, Turkey -- [Erdis, Eda] Cumhuriyet Univ, Sch Med, Div Radiat Oncol, TR-58140 Sivas, Turkey -- [Kaya, Mehmet Gungor] Erciyes Univ, Sch Med, Div Cardiol, Kayseri, Turkeyen_US
dc.description.abstractObjectives: Patients with rheumatoid arthritis (RA) are known to be at increased cardiovascular risk. Etanercept is a tumor necrosis factor alpha (TNF-alpha) blocking agent that has been successfully used in the treatment of RA. We sought to assess the effects of etanercept on cardiac functions and lipid profile in RA patients without overt cardiac disease. Methods: Sixteen patients with active RA were recruited to the study prospectively. Etanercept was administered subcutaneously twice a week for 6 months. Clinical and laboratory predictors of RA activity and lipid profile were evaluated at baseline and at 6 months. The systolic and diastolic function parameters of the left ventricle were obtained by echocardiographic examination and included mitral inflow Doppler and tissue Doppler imaging. Results: Sixteen patients (13 women; median age, 48 years [range, 27-69 years]) completed the study. Patients' 28-item Disease Activity Score and Health Assessment Questionnaire scores were significantly reduced by treatment (6.35 to 4.45 [P < 0.001] and 2.0 to 0.75 [P = 0.005], respectively). Diastolic dysfunction was detected in 6 patients (37.5%) (3 in grade 1 and 3 in grade 2) by mitral inflow Doppler and the tissue Doppler parameters before the treatment. No significant change in diastolic dysfunction was observed during follow-up (6/16 to 5/16, P = 0.164). In addition, there were also no significant differences in the left ventricular ejection fraction (65.8-66.9, P = 0.168) and lipid profiles after 6 months of etanercept treatment. Conclusions: Etanercept treatment was safe for use as regards cardiac functions and lipid profiles and effective on RA parameters during 6-month follow-up in patients with active RA.en_US
dc.identifier.endpage65en_US
dc.identifier.issn1081-5589
dc.identifier.issue1en_US
dc.identifier.pmid22064606en_US
dc.identifier.scopus2-s2.0-84856743812en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage62en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9371
dc.identifier.volume60en_US
dc.identifier.wosWOS:000298634400018en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJOURNAL OF INVESTIGATIVE MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectetanercepten_US
dc.subjectlipid profileen_US
dc.subjectcardiac functionen_US
dc.subjectechocardiographyen_US
dc.titleThe Safety and Efficacy of Etanercept on Cardiac Functions and Lipid Profile in Patients With Active Rheumatoid Arthritisen_US
dc.typeArticleen_US

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