Association Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virus

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dc.contributor.authorTimucin, Meryem
dc.contributor.authorAlagozlu, Hakan
dc.contributor.authorOzdemir, Semra
dc.contributor.authorOzdemir, Ozturk
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:00:03Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:00:03Z
dc.date.issued2013
dc.department[Timucin, Meryem -- Alagozlu, Hakan] Cumhuriyet Univ, Fac Med, Dept Gastroenterol, Sivas, Turkey -- [Ozdemir, Semra] Canakkale Onsekiz Mart Univ, Fac Med, Dept Nucl Med, TR-17100 Canakkale, Turkey -- [Ozdemir, Ozturk] Cumhuriyet Univ, Dept Med Genet, Fac Med, Sivas, Turkey -- [Ozdemir, Ozturk] Canakkale Onsekiz Mart Univ, Dept Med Genet, Fac Med, TR-17100 Canakkale, Turkeyen_US
dc.description.abstractBackground: To treat viral infection of chronic hepatitis C (CHC) is a main strategy to prevent progression of liver disease, and cancer. Some patients with CHC have failed to respond to the common antiviral therapy in different populations. Objectives: In the current study it was aimed to find out the possible role of multiple drug resistance gene1 (MDR1) in non-responder patients with CHC infection in Turkish population. Patients and Methods: Peripheral blood-EDTA samples were used for total genomic DNA isolation. In total of 55 patients with chronic hepatitis C and positive results for genotype 1 [31 male (56.4%), 24 female (43.6%) and mean age-min-max; 56.9 +/- 9.66 (39-71)]; 19 responder (34.5%), 21 non responder (38.2%), and 15 recurrence (27.3%) were included in the presented results. Functional MDR1 gene was genotyped by multiplex PCR-based reverse-hybridization Strip Assay method, and some samples were confirmed by direct sequencing. Results: Our results indicate that MDR1 gene polymorphism is strongly associated with non-responder patients and those with recurrent chronic hepatitis C during conventional drug therapy when compared to the responder patients. Homozygous of the TT genotype for MDR1 exon 26 polymorphism was at 2.0-fold higher risk of non-responder than patients with CC and CT. Conclusions: The homozygous MDR1 3435TT genotype which encodes the xenobiotic transporter P-glycoprotein may be associated with a poor antiviral response in HCV chronicity during conventional therapy, and large-scale studies are needed to validate this association.en_US
dc.identifier.doi10.5812/hepatmon.7522en_US
dc.identifier.issn1735-143X
dc.identifier.issn1735-3408
dc.identifier.issue4en_US
dc.identifier.pmid23805158en_US
dc.identifier.scopus2-s2.0-84876245326en_US
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://dx.doi.org/10.5812/hepatmon.7522
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8738
dc.identifier.volume13en_US
dc.identifier.wosWOS:000322122800008en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKOWSAR PUBLen_US
dc.relation.ispartofHEPATITIS MONTHLYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis Cen_US
dc.subjectData Collectionen_US
dc.subjectP Glycoproteinen_US
dc.titleAssociation Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virusen_US
dc.typeArticleen_US

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