Microsomal epoxide hydrolase polymorphisms

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dc.contributor.authorPinarbasi, Hatice
dc.contributor.authorSilig, Yavuz
dc.contributor.authorPinarbasi, Ergun
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:13:40Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:13:40Z
dc.date.issued2010
dc.department[Pinarbasi, Hatice -- Silig, Yavuz] Cumhuriyet Univ, Dept Biochem, Fac Med, TR-58140 Sivas, Turkey -- [Pinarbasi, Ergun] Cumhuriyet Univ, Dept Med Biol, Fac Med, TR-58140 Sivas, Turkeyen_US
dc.description.abstractMicrosomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change tyrosine residue 113 to histidine (Tyr113His) and histidine 139 to arginine (His139Arg), respectively. The exon 3 polymorphism reduces enzyme activity by approximately 50%, whereas the exon 4 polymorphism causes a 25% increase in activity. In the present study, the distribution of these polymorphisms in a Turkish population including 625 unrelated healthy individuals was examined using a PCR-RFLP method. The observed genotype frequencies of microsomal epoxide hydrolase exon 3 were 54,38 and 8% for Tyr113Tyr, Tyr113His and His113His, respectively. Exon 4 genotype frequencies were found to be 69, 29 and 2% for His139His, His139Arg and Arg139Arg, respectively.en_US
dc.description.sponsorshipCumhuriyet University CU BAP, Sivas, Turkey [T-277]en_US
dc.description.sponsorshipThis work was supported by grant no. T-277 from the Cumhuriyet University CU BAP, Sivas, Turkey.en_US
dc.identifier.doi10.3892/mmr_00000324en_US
dc.identifier.endpage727en_US
dc.identifier.issn1791-2997
dc.identifier.issue4en_US
dc.identifier.pmid21472306en_US
dc.identifier.scopus2-s2.0-77956684345en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage723en_US
dc.identifier.urihttps://dx.doi.org/10.3892/mmr_00000324
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9850
dc.identifier.volume3en_US
dc.identifier.wosWOS:000279207000030en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPANDIDOS PUBL LTDen_US
dc.relation.ispartofMOLECULAR MEDICINE REPORTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmicrosomal epoxide hydrolaseen_US
dc.subjectpolymorphismen_US
dc.titleMicrosomal epoxide hydrolase polymorphismsen_US
dc.typeArticleen_US

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