Antimicrobial synergism and antibiofilm activities of Pelargonium graveolens, Rosemary officinalis, and Mentha piperita essential oils against extreme drug-resistant Acinetobacter baumannii clinical isolates

Taşkın Kafa, Ayşe Hümeyra; Aslan, Rukiye; Çelik, Cem; Hasbek, Mürşit

Antimicrobial synergism and antibiofilm activities of Pelargonium graveolens, Rosemary officinalis, and Mentha piperita essential oils against extreme drug-resistant Acinetobacter baumannii clinical isolates

dc.authorid	0000-0002-7282-4928	tr
dc.contributor.author	Taşkın Kafa, Ayşe Hümeyra
dc.contributor.author	Aslan, Rukiye
dc.contributor.author	Çelik, Cem
dc.contributor.author	Hasbek, Mürşit
dc.date.accessioned	2023-06-22T11:58:38Z
dc.date.available	2023-06-22T11:58:38Z
dc.date.issued	28 Mart 2022	tr
dc.department	Tıp Fakültesi	tr
dc.description.abstract	Rosemary officinalis L., Pelargonium graveolens L., and Mentha piperita L., essential oils are used by complementary medicine specialists simultaneously with traditional antibiotics for treatment purposes. The chemical composition of essential oils was analyzed by the gas chromatography-mass spectrometry method. In vitro antibacterial and antibiofilm activities of the essential oils were tested against extreme drug-resistant (XDR) colistin-resistant and colistin susceptible Acinetobacter baumannii clinical strains. The synergistic activities between essential oils and colistin antibiotics were investigated by the checkerboard method. The highest antibacterial effect was detected in mint essential oil (2.5-5 μl/ml), followed by pelargonium essential oil (5-20 μl/ml) and rosemary essential oil (5-20 μl/ml). The combination of rosemary essential oil or pelargonium essential oil with colistin showed strong synergistic activity in most of the bacterial strains tested (fractional inhibitory concentration index ≤ 0.5; synergy). As a result of the combination of mint essential oil and colistin, an indifferent effect was observed in only two bacterial strains, and other strains could not be evaluated. No antagonistic effects were observed in any of the tested essential oils. As a result of the effectiveness of the combination, the minimum inhibitory concentration (MIC) values of colistin in XDR-A. baumannii clinical isolates decreased 2-32 fold. Additionally, the sub-MIC concentration of essential oils exhibited an inhibitory effect (48-90%) against the biofilm layer of tested A. baumannii strains.	tr
dc.identifier.pmid	34142518	en_US
dc.identifier.scopus	2-s2.0-85109012778	en_US
dc.identifier.scopusquality	N/A
dc.identifier.uri	https://hdl.handle.net/20.500.12418/13964
dc.identifier.wos	WOS:000744123200001	en_US
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science	en_US
dc.indekslendigikaynak	Scopus	en_US
dc.indekslendigikaynak	PubMed	en_US
dc.language.iso	en	en_US
dc.relation.publicationcategory	Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı	tr
dc.rights	info:eu-repo/semantics/openAccess	tr
dc.title	Antimicrobial synergism and antibiofilm activities of Pelargonium graveolens, Rosemary officinalis, and Mentha piperita essential oils against extreme drug-resistant Acinetobacter baumannii clinical isolates	en_US
dc.type	Article	en_US