Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes

Basit Öğe Kaydı
dc.authorid0000-0003-1498-4170tr
dc.contributor.authorŞahin, Neslihan
dc.contributor.authorÜstün, Elvan
dc.contributor.authorÇelik, Cem
dc.contributor.authorTutar, Uğur
dc.contributor.authorÖzdemir, Namık
dc.contributor.authorGürbüz, Nevin
dc.contributor.authorÖzdemir, İsmail
dc.date.accessioned2022-05-13T07:51:25Z
dc.date.available2022-05-13T07:51:25Z
dc.date.issued2021tr
dc.departmentEğitim Fakültesitr
dc.description.abstractMicroorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition of formation of biofilms through hindering of quorum sensing could be a method for the production of new generation antibiotics. In this study, four new benzimidazole type NHC precursors (1-allyl- 3-benzyl-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,4,6-trimethylbenzyl)-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,3,5,6-tetramethylbenzyl)-5,6-dimethylbenzimidazolium chloride, and 1-allyl-3-(2,3,4,5,6-pentamethylbenzyl)-5,6-dimethylbenzimidazolium chloride and Ag-NHC complexes of these molecules were synthesized and characterized by elemental analysis, FT-IR spectroscopy, 1H, and 13C{1H} NMR spectroscopy, LC-MS, and single crystal crystallography. Antimicrobial and biofilm formation inhibition activities of the molecules were evaluated. In addition, the activities of the molecules were examined in detail by molecular docking analysis. According to the results obtained, higher activity was achieved with the complex molecules when compared with the benzimidazole derivative ligands.tr
dc.identifier.citationÜstün, E., Şahin, N., Çelik, C., Tutar, U., Özdemir, N., Gürbüz, N., & Özdemir, İ. (2021). Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes. Dalton Transactions, 50(42), 15400-15412.tr
dc.identifier.doi10.1039/d1dt02003jen_US
dc.identifier.endpage15412tr
dc.identifier.issue42tr
dc.identifier.pmid34647935en_US
dc.identifier.scopus2-s2.0-85118943371en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage15400tr
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2021/dt/d1dt02003j/unauth
dc.identifier.urihttps://hdl.handle.net/20.500.12418/12979
dc.identifier.volume50tr
dc.identifier.wosWOS:000707138600001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofDalton Transactionsen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/closedAccesstr
dc.subjectN-heterocyclic carbenetr
dc.subjectbenzimidazoletr
dc.subjectantibiofilm activitytr
dc.titleSynthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexesen_US
dc.typeArticleen_US

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