Doxorubicin and tamoxifen loaded graphene oxide nanoparticle functionalized with chitosan and folic acid for anticancer drug delivery.

Keklikcioğlu Çakmak, Neşe; Eroğlu, Atakan

Doxorubicin and tamoxifen loaded graphene oxide nanoparticle functionalized with chitosan and folic acid for anticancer drug delivery.

dc.authorid	0000-0002-8634-9232	tr
dc.contributor.author	Keklikcioğlu Çakmak, Neşe
dc.contributor.author	Eroğlu, Atakan
dc.date.accessioned	2024-03-04T11:17:29Z
dc.date.available	2024-03-04T11:17:29Z
dc.date.issued	February 2023	tr
dc.department	Mühendislik Fakültesi	tr
dc.description.abstract	Research has commonly utilized graphene-based drug delivery systems for a long time to achieve efective cancer treatment. In the present study, doxorubicin (DOX) and selective estrogen receptor modulator tamoxifen (TAM) anticancer drugs used in breast cancer treatment were bound to a graphene oxide (GO)-based and folic acid (FA)-targeted nanocarrier system that was made biocompatible with chitosan (CS). To this end, graphene oxide synthesis was primarily carried out by employing the modifed Hummer’s method, and then FA and CS were loaded on GO to obtain a targeted and biocompatible carrier The characterization of the obtained conjugate was performed by X-ray difraction analysis, Fourier transform infrared spectroscopy, UV-visible spectrophotometry, scanning electron microscopy, and zeta potential analysis. The zeta potential values of all samples were checked and all of them have a zeta potential above the stability value of±25 mV. GO-CS-FA has the highest zeta potential of 68.8 mV. The graphene oxide-chitosan-folic acidtamoxifen-doxorubicin (GO-CS-FA-TAM-DOX) nanocarrier-based drug displayed a pH-dependent drug release. The drug release profle from these systems was researched in two pH bufer solutions prepared as acidic (pH 5.8) and physiological (pH 7.4). The characterization analyses showed that the drugs bound successfully to the targeted delivery system. The drug release analyses demonstrated that GO-CSFA-TAM-DOX was released better in the acidic (pH 5.8) medium compared to the physiological (pH 7.4) medium after 24 h.	tr
dc.identifier.doi	10.1007/s00289-022-04549-9	en_US
dc.identifier.scopus	2-s2.0-85141676255	en_US
dc.identifier.scopusquality	N/A
dc.identifier.uri	https://hdl.handle.net/20.500.12418/14586
dc.identifier.wos	WOS:000882354900002	en_US
dc.identifier.wosquality	Q2
dc.indekslendigikaynak	Web of Science	en_US
dc.indekslendigikaynak	Scopus	en_US
dc.language.iso	en	en_US
dc.relation.publicationcategory	Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı	tr
dc.rights	info:eu-repo/semantics/openAccess	tr
dc.subject	Doxorubicin · Tamoxifen · Folic acid · Chitosan · Graphene oxide · Stability · Zeta potential	tr
dc.title	Doxorubicin and tamoxifen loaded graphene oxide nanoparticle functionalized with chitosan and folic acid for anticancer drug delivery.	en_US
dc.type	Article	en_US