Role of dopaminergic system in oxytocin analgesia: The missing part in a puzzle

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dc.authoridTaskiran, Ahmet Sevki/0000-0002-5810-8415
dc.authoridGulmez, Kader/0000-0001-6648-2397
dc.authoridCIMEN, KAAN/0000-0001-9781-7815
dc.contributor.authorTastemur, Yasar
dc.contributor.authorTaskiran, Ahmet Sevki
dc.contributor.authorAltun, Ahmet
dc.contributor.authorFiliz, Ahmet Kemal
dc.contributor.authorGulmez, Kader
dc.contributor.authorCimen, Kaan
dc.contributor.authorOzdemir, Ercan
dc.date.accessioned2024-10-26T18:02:21Z
dc.date.available2024-10-26T18:02:21Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: To investigate the analgesic effects of oxytocin (OT) and elucidate the role of dopaminergic system in its mechanisms. Methods: In this study, 72 male (n=6 for each group) 230-250 gr Wistar Albino rats were used. Firstly, dose studies were performed with 100 mu g/kg, 200 mu g/kg and 400 mu g/kg to determine the optimal analgesic effect of oxytocin. Optimal dose was found at 200 mu g/kg, and then animals were divided into nine groups: Saline, D1 agonist (SKF 38393; 0.1 mg/kg), D1 antagonist (SCH-23390; 0.1 mg/kg), D1 agonist + oxytocin, D1 antagonist + oxytocin, D2 agonist (Cabergoline; 0,5 mg/kg), D2 antagonist (Sulpride; 10 mg/kg), D2 agonist + oxytocin and D2 antagonist + oxytocin. Serum physiologic saline was given to the saline group and other drugs were administered intraperitoneally at the indicated doses. Tail-flick and hot-plate tests were used to measure analgesic effects. Analgesic tests were measured in 30 min-intervals (at 30th, 60th, 90th, and 120th min) and recorded in seconds. To evaluate maximum antinociceptive effect (% MPE), the tail-flick and hot-plate latencies were converted to the antinociceptive effectiveness Results: The results show that D1 antagonist SCH-23390 (0.1 mg/kg) and D2 agonist cabergoline (0.5 mg/kg) created strong analgesia while the D1 agonist SKF 38393 (0.1 mg/kg) and D2 antagonist sulpiride (10 mg/kg) did not have any analgesic effect. However, only D2 antagonist sulpiride blocked the analgesic effect produced by OT Conclusion: OT may be one of the primary agents participating in spinal analgesia, and the dopaminergic system is one of the central mechanisms of action for this important molecule. The dopaminergic system may also be one of the targets for 'descending' analgesic system.
dc.identifier.doi10.4314/tjpr.v19i5.26
dc.identifier.endpage1092
dc.identifier.issn1596-5996
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85086239161
dc.identifier.scopusqualityQ3
dc.identifier.startpage1087
dc.identifier.urihttps://doi.org/10.4314/tjpr.v19i5.26
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28080
dc.identifier.volume19
dc.identifier.wosWOS:000537871800026
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPharmacotherapy Group
dc.relation.ispartofTropical Journal of Pharmaceutical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOxytocin
dc.subjectTail flick
dc.subjectHot plate
dc.subjectDopaminergic
dc.subjectAnalgesic
dc.subjectAntagonist
dc.subjectAgonist
dc.titleRole of dopaminergic system in oxytocin analgesia: The missing part in a puzzle
dc.typeArticle

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