Comparison of the effect of Triticum Vulgare and Hyperici Oleum on healing in traumatic membrane perforation: an animal study

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dc.authoridDemirkiran, Berat Baturay/0000-0003-3543-1137
dc.authoridAltuntas, Emine Elif/0000-0003-4503-3730
dc.authoridBora, Adem/0000-0002-5036-0595
dc.contributor.authorBora, Adem
dc.contributor.authorDurmus, Kasim
dc.contributor.authorInan, Zeynep D. Sahin
dc.contributor.authorDemirkiran, Berat Baturay
dc.contributor.authorAltuntas, Emine E.
dc.date.accessioned2024-10-26T18:04:11Z
dc.date.available2024-10-26T18:04:11Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackgroundTraumatic tympanic membrane (TM) perforations usually heal spontaneously. The aim of this study was to investigate whether the topical application of Triticum Vulgare (TV) in experimentally induced traumatic TM perforations in the rats has a positive effect on wound healing process.MethodsThe rats were randomly assigned to four experimental groups. Drugs were introduced twice a day for 7 days. On the 7th day, specimens were sent for histological examination.ResultsMean values found in group NC in terms of epithelial regeneration mean scores are as follows: fibroblast and collagen density, neovascularization, and density of inflammation cells were lower than all groups (p < 0.05).It was found that reepithelization on the post-perforation 7th day was better in the HO group than the TV group. In terms of the subepithelial fibroblast cells, density of collagen fibers, formation of new veins, and inflammatory cell accumulation, it was observed that the group TV was better than the group HO.ConclusionThis is the first study investigating the potential curative role of TV in an experimental rat model of tympanic membrane perforation. Considering these findings, it is concluded that TV can be more effective than HO on wound healing in TM perforation.
dc.identifier.doi10.1186/s43163-023-00389-0
dc.identifier.issn1012-5574
dc.identifier.issn2090-8539
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85146947283
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1186/s43163-023-00389-0
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28782
dc.identifier.volume39
dc.identifier.wosWOS:000918605700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEgyptian Journal of Otolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHyperici oleum
dc.subjectTriticum vulgare
dc.subjectTraumatic tympanic membrane perforation
dc.titleComparison of the effect of Triticum Vulgare and Hyperici Oleum on healing in traumatic membrane perforation: an animal study
dc.typeArticle

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