Association of MCP-1 promotor polymorphism with disease severity of Crimean-Congo hemorrhagic fever

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dc.authoridBagci, Gokhan/0000-0003-4554-2391
dc.authoridBUYUKTUNA, SEYIT ALI/0000-0001-6518-7361
dc.authoridbagci, binnur/0000-0003-1323-3359
dc.contributor.authorBagci, Binnur
dc.contributor.authorBagci, Gokhan
dc.contributor.authorBuyuktuna, Seyit Ali
dc.contributor.authorElaldi, Nazif
dc.date.accessioned2024-10-26T18:07:21Z
dc.date.available2024-10-26T18:07:21Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCrimean-Congo hemorrhagic fever (CCHF) is a thick-borne viral zoonotic disease. The pathogenesis and the reasons why cases have a mild or severe course in CCHF have not yet been explained. In this study, we investigated the relationship between promoter -2518 A/G single-nucleotide polymorphism (SNP) of the MCP-1 gene and the clinical course of CCHF. The MCP-1-2518 A/G SNP (rs1024611) frequency was examined in 128 virologically/serologically confirmed CCHF patients and 181 healthy controls by using the PCR-RFLP method. When CCHF patients and controls were compared, no significant difference was found between genotype distributions and allele frequencies of the -2518 A/G SNP of MCP-1 gene (P > .05). Compared to the AA genotype, both AG (P = .016; OR = 2.57) and GG genotype (P = .039; OR = 3.43) were found with significantly higher frequencies in mild/moderate cases than in severe cases. Compared to the AG + GG genotype, AA showed a significant risk for severe CCHF (60.0% vs 38.4%, P = .02; OR = 2.41). In contrast, the AG genotype showed a significant protective effect against severe disease compared to AA + GG genotype (29.1% vs 47.9%, P = .013; OR = 2.58). Compared to mild/moderate cases, the A allele was found to be significantly higher in severe cases (0.745 vs 0.623, P = .039; OR = 1.77). However, no significant relationship was found between fatal and nonfatal cases in terms of genotype or allele frequencies (P > .05). In conclusion, both -2518 AA genotype and A allele of MCP-1 were associated with disease severity, and the AG genotype had a protective effect against a severe disease course in CCHF patients.
dc.identifier.doi10.1002/jmv.25790
dc.identifier.endpage2982
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue12
dc.identifier.pmid32219866
dc.identifier.scopus2-s2.0-85082941455
dc.identifier.scopusqualityQ1
dc.identifier.startpage2976
dc.identifier.urihttps://doi.org/10.1002/jmv.25790
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29465
dc.identifier.volume92
dc.identifier.wosWOS:000523224400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrimean-Congo hemorrhagic fever
dc.subjectdisease severity
dc.subjectgene polymorphism
dc.subjectMCP-1
dc.subjectmonocyte chemoattractant protein
dc.titleAssociation of MCP-1 promotor polymorphism with disease severity of Crimean-Congo hemorrhagic fever
dc.typeArticle

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