New prognostic markers in pulmonary arterial hypertension: CRP to albumin ratio and uric acid

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dc.authoridSahin, Anil/0000-0003-3416-5965
dc.contributor.authorCerik, Idris Bugra
dc.contributor.authorDindas, Ferhat
dc.contributor.authorKoyun, Emin
dc.contributor.authorDereli, Seckin
dc.contributor.authorSahin, Anil
dc.contributor.authorTurgut, Okan Onur
dc.contributor.authorGul, Ibrahim
dc.date.accessioned2024-10-26T18:09:37Z
dc.date.available2024-10-26T18:09:37Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: Idiopathic pulmonary hypertension(IPAH) is a rare disease that causes severe morbidity and mortality despite advances in treatment management. Evaluating the prognosis of the disease is critical in determining therapeutic approaches. We aimed to evaluate the prognostic significance of C-reactive protein/albumin ratio (CAR) and uric acid, which is an easily applicable and inexpensive parameter in patients with IPAH. Methods: Seventy-two IPAH patients and 99 consecutive non-IPAH patients as a control group were enrolled in the study retrospectively. Right heart catheterization(RHC), echocardiography, and laboratory parameters of the two groups and those who died and survived among the IPAH patients were compared. Results: IPAH and control group were compared at the first stage and CAR (1.98(0.28-10.74), 0.75(0.22-4.7), respectively;p < 0.01) and uric acid (0.33(0.19-0.87), 0.3(0.11-0.48) mmol/L, respectively; p = 0.03) values were significantly higher in the pulmonary hypertension group compared to the control group. Compared with the surviving IPAH patients, CAR (4.60(1.39-10.74),1.54(0.28-6.74),respectively;p < 0.001) and uric acid levels (0.458(0.26-0.87), 0.315(0.19-0.56) mmol/L, respectively; p < 0.001) were significantly higher in the group of patients who died. In the multivariate Cox regression models uric acid(p < 0.001) and CAR(p < 0.001) were found to be associated with survival time. Receiver operating characteristic curves (ROC) analyses showed that > 1.54 CAR value (AUC = 0.81,Sens:85.7%,Spec:56.9%,p < 0.001) and > 5.85 mg/dL (>0.348 mmol/L) uric acid value (AUC = 0.864, Sens:85.7%, Spec:78.4%, p < 0.001) are strong predictors for mortality. Conclusion: In this study, we showed that simple markers such as CAR, which augment the inflammation marker feature of CRP, and uric acid can give prognostic information in PAH patients.
dc.identifier.doi10.1016/j.clinbiochem.2021.11.004
dc.identifier.endpage28
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.pmid34788635
dc.identifier.scopus2-s2.0-85120381608
dc.identifier.scopusqualityQ2
dc.identifier.startpage22
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2021.11.004
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30178
dc.identifier.volume100
dc.identifier.wosWOS:000850848000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofClinical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPulmonary hypertension
dc.subjectSurvival
dc.subjectPrognosis
dc.subjectC-reactive protein
dc.subjectAlbumin
dc.subjectUric acid
dc.titleNew prognostic markers in pulmonary arterial hypertension: CRP to albumin ratio and uric acid
dc.typeArticle

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