Oxidative Stress Levels and Dynamic Thiol-Disulfide Balance in Preterm Newborns with Bronchopulmonary Dysplasia

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dc.authoridKilicbay, Fatih/0000-0001-9073-0864
dc.authoridErdal, Huseyin/0000-0003-0786-5077
dc.authoridDemirtas, Mehmet Semih/0000-0003-2965-1811
dc.authoridTunc, Gaffari/0000-0001-7837-3948
dc.contributor.authorDemirtas, Mehmet Semih
dc.contributor.authorKilicbay, Fatih
dc.contributor.authorErdal, Huseyin
dc.contributor.authorTunc, Gaffari
dc.date.accessioned2024-10-26T18:07:39Z
dc.date.available2024-10-26T18:07:39Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective The aim of this study was to assess the oxidative stress (OS) levels and dynamic thiol-disulfide balance in preterm newborns with bronchopulmonary dysplasia (BPD). Methods This prospective study included newborns separated into 2 groups, those with BPD (case) or without BPD (control). The 2 groups were compared by clinical and laboratory findings. The OS parameters total oxidant status (TOS), total antioxidant status (TAS), OS index (OSI), native thiol (NT), and total thiol were measured within the first day after birth. Oxygen requirements were measured using the fraction of inspired oxygen (FIO2) recorded in the first hour after birth/admission and the average FIO2 within 28 days of the birth. Results Infants diagnosed with BPD had a significantly lower gestational age and birth weight and a lower 5-min Apgar score (P < .05). Infants with BPD also had a higher rate of respiratory distress syndrome, rate of use of surfactant therapy, duration of ventilation therapy, and duration of hospital stay compared with control (P = .001, P = .001, P = .001, and P = .001, respectively). Plasma TAS and NT levels of newborns with BPD were significantly lower than newborns without BPD (P < .05). In the BPD group, plasma TOS and OSI levels were significantly higher than in the control group. Conclusion We found that OS was increased in newborns with BPD. The clinical significance of this study will provide the clinician with a different perspective on BPD by determining the dynamic thiol disulfide balance.
dc.identifier.doi10.1093/labmed/lmad010
dc.identifier.endpage592
dc.identifier.issn0007-5027
dc.identifier.issn1943-7730
dc.identifier.issue6
dc.identifier.pmid36896684
dc.identifier.scopus2-s2.0-85151001889
dc.identifier.scopusqualityQ3
dc.identifier.startpage587
dc.identifier.urihttps://doi.org/10.1093/labmed/lmad010
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29622
dc.identifier.volume54
dc.identifier.wosWOS:000946538000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofLaboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectnewborn
dc.subjectbronchopulmonary dysplasia
dc.subjectthiol-disulfide homeostasis
dc.subjectoxidative stress
dc.titleOxidative Stress Levels and Dynamic Thiol-Disulfide Balance in Preterm Newborns with Bronchopulmonary Dysplasia
dc.typeArticle

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