Crossflow ultraflitration of binary biomolecule mixture: Analysis of permeate flux, cake resistance and sieving coefficient

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dc.contributor.authorSalgin, Ugur
dc.contributor.authorSalgin, Sema
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:16:46Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:16:46Z
dc.date.issued2007
dc.departmentCumhuriyet Univ, Fac Engn, Dept Chem Engn, TR-58140 Sivas, Turkeyen_US
dc.description.abstractThe aim of this paper is to demonstrate the effects of hydrodynamic conditions on the permeate flux, cake resistance and sieving coefficient in a crossflow ultrafiltration process separating biomolecules of different molecular weights. A binary mixture of L-phenylalanine (L-phe) and lipase was ultrafiltered through a hydrophobic polyether sulphone (PES) membrane with 10 kDa molecular weight cut-off. The changes in permeate flux, cake layer resistance and observed sieving coefficient with different transmembrane pressures (TMP) and crossflow velocities were evaluated. The effect of TMP was examined at two different velocities (0.114 m s(-1) and 0.176 in s(-1)) and the effect of velocity was examined at two different TMP (20 kPa and 115 kPa) for the experimental system designed. In the initial stage of the crossflow filtration, it was determined that the TMP was more effective than the velocity. The cake layer resistance increased with increasing TMP and it decreased with increasing velocity for the high TMP value of 115 kPa. A maximum of the observed sieving coefficient was achieved with increasing velocity. An increase in TMP at low inlet velocity (0.114 in s(-1)) affected the observed sieving coefficient positively.en_US
dc.identifier.doi10.1002/ceat.200600372en_US
dc.identifier.endpage492en_US
dc.identifier.issn0930-7516
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-34247274675en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage487en_US
dc.identifier.urihttps://dx.doi.org/10.1002/ceat.200600372
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10630
dc.identifier.volume30en_US
dc.identifier.wosWOS:000245734400009en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.relation.ispartofCHEMICAL ENGINEERING & TECHNOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiomoleculesen_US
dc.subjectcrossflow ultrafiltrationen_US
dc.subjectmembranesen_US
dc.titleCrossflow ultraflitration of binary biomolecule mixture: Analysis of permeate flux, cake resistance and sieving coefficienten_US
dc.typeArticleen_US

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