Investigation of the miRNA levels changes to acceptable daily intake dose pesticide mixture exposure on rat mesentery and pancreas

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dc.contributor.authorSevim, Cigdem
dc.contributor.authorTsatsakis, Aristides
dc.contributor.authorTaghizadehghalehjoughi, Ali
dc.contributor.authorOzkaraca, Mustafa
dc.contributor.authorKara, Mehtap
dc.contributor.authorGenc, Sidika
dc.contributor.authorMendil, Ali Sefa
dc.date.accessioned2024-10-26T17:51:37Z
dc.date.available2024-10-26T17:51:37Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractConsumers are constantly exposed to a variety of chemical mixtures as part of their everyday activities and lifestyle. Food, water and commercial products are only some examples of the possible ways people get exposed to these mixtures. However, following federal and local guidelines for risk assessment related to chemical exposure, risk analysis focuses on a single substance exposure scenario and not on a mixture, as in real life. Realizing the pronounced gap of this methodology, the real-life risk simulation scenario approach tries to address this problem by investigating the possible effect of long-term exposure to chemical mixtures closely resembling the actual circumstances of modern life. As part of this effort, this study aimed to identify the cumulative effects of pesticides belonging to different classes and commonly used commercial products on long-term exposure with realistic doses. Sprague Dawley rats were given a pesticide mix of active ingredients and formulation chemicals in a daily acceptable dose (ADI) and 10xADI for 90 days. Following thorough everyday documentation of possible side-effects, after 90 days all animals were sacrificed and their organs were examined. Exposure to pesticides particularly affects the miRNA levels at that point will provide us with more information about whether they can be potential biomarkers. © 2023 The Authors
dc.description.sponsorshipKastamonu Üniversitesi, (KÜ-BAP01/2021–33)
dc.identifier.doi10.1016/j.chemosphere.2023.140712
dc.identifier.issn0045-6535
dc.identifier.pmid38036224
dc.identifier.scopus2-s2.0-85179096187
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.chemosphere.2023.140712
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26339
dc.identifier.volume349
dc.identifier.wosWOS:001325675700813
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofChemosphere
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChlormequat; Chlorpyrifos-methyl; Deltamethrin; Glyphosate; Pirimiphos-methyl; Tebuconazole
dc.titleInvestigation of the miRNA levels changes to acceptable daily intake dose pesticide mixture exposure on rat mesentery and pancreas
dc.typeArticle

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