An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media

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dc.contributor.authorDurmus, Kasim
dc.contributor.authorKurtulgan, Hande Kucuk
dc.contributor.authorBora, Adem
dc.contributor.authorYildirim, Malik Ejder
dc.contributor.authorAltuntas, Emine Elif
dc.date.accessioned2024-10-26T18:00:15Z
dc.date.available2024-10-26T18:00:15Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation which lies at the heart of the disorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene. Methods: We investigated 49 patients admitted to the Otorhinolaryngology Department of Cumhuriyet University and diagnosed with COM between September and November 2017. The control group consisted of 51 healthy individuals. Polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) methods were used to genotype the PON1 Q192R (rs662) polymorphism. Results: When the case and control groups were compared in terms of the existence of PON1 (Q192) polymorphism, there was no statistically significant difference between the groups (p=0.166, p>0.05). When intergroup comparison was performed on the type of PON1 (Q192) polymorphism, there was also no statistically significant difference (p=0.261, p>0.05). Conclusion: The present study is the first known study in which PON1 polymorphism has been examined in cases of COM. The results of our study failed to indicate a statistically significant relationship between PON1 polymorphism and COM. However, it is important to note that the higher rate of 192RR polymorphism within the control group may indicate a protective effect in COM.
dc.identifier.doi10.32448/entupdates.594272
dc.identifier.endpage237
dc.identifier.issn2149-7109
dc.identifier.issn2149-6498
dc.identifier.issue1
dc.identifier.startpage232
dc.identifier.trdizinid387858
dc.identifier.urihttps://doi.org/10.32448/entupdates.594272
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/387858
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27587
dc.identifier.volume10
dc.identifier.wosWOS:000605956400002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherDergipark Akad
dc.relation.ispartofEnt Updates
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOtitis media
dc.subjectoxidative stress
dc.subjectparaoxonase-1
dc.subjectgenetic polymorphism
dc.titleAn Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media
dc.typeArticle

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