Development of phytoactive essential oils-composed organogels against oral pathogens

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dc.contributor.authorYapar, Evren Algin
dc.contributor.authorGokce, Evren H.
dc.contributor.authorSahiner, Asli
dc.contributor.authorInal, Ebrar
dc.contributor.authorUlusoy, Seyma
dc.contributor.authorSouto, Eliana B.
dc.contributor.authorAkanoglu, Beyza
dc.date.accessioned2024-10-26T18:09:28Z
dc.date.available2024-10-26T18:09:28Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractGingivitis, one of the most common periodontal diseases, is the inflammation of the gingival tissues that causes swelling, tenderness, redness and bleeding. The treatment should contain anti-inflammatory, antibacterial, and antioxidant agents to decrease the risk of dental plaque formation and periodontal tissue damage in the inflammatory process. In line with the antibacterial, antifungal, and antioxidant effects of the geranium (Pelargonium graveolens L'Her.) herb, common sage (Salvia officinalis L.) herb, and mastic tree (Pistacia lentiscus L.) leaf, in this work we propose their use as active pharmaceutical ingredients of periodontal gels. The organogel formulations were produced either by microwave-assisted irradiation method or by the conventional approach (microwave-free), and further characterized for their physicochemical properties, antimicrobial efficacy and cell viability. Among them, the gel formulation containing 4 % geranium essential oil obtained by the conventional method was identified as the best candidate to be developed as an effective and safe alternative suitable for oromucosal applications.
dc.description.sponsorshipBezmialem Vakimath;f University Scientific Research Projects [20220210]; FCT-Fundacao para a Ciencia e a Tecnologia, I.P., Lisbon, Portugal
dc.description.sponsorshipThis study is a part of project, which is supported by Bezmialem Vak & imath;f University Scientific Research Projects (number 20220210) . Eliana B. Souto acknowledges FCT-Fundacao para a Ciencia e a Tecnologia, I.P., Lisbon, Portugal.
dc.identifier.doi10.1016/j.jddst.2024.105778
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85193451903
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2024.105778
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30129
dc.identifier.volume97
dc.identifier.wosWOS:001326786000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMastic tree
dc.subjectPistacia lentiscus L.
dc.subjectCommon sage
dc.subjectGeranium Pelargonium graveolens L'Her
dc.titleDevelopment of phytoactive essential oils-composed organogels against oral pathogens
dc.typeArticle

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