A novel, conserved and possibly functional motif “WHWGHTW” in mitochondrial transcription across Bilateria

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dc.authorid0000-0003-0699-1354tr
dc.contributor.authorAydemir, Merve Nur
dc.contributor.authorAydemir, Habeş Bilal
dc.contributor.authorBudak, Mahir
dc.contributor.authorKızıltepe, Birsel
dc.contributor.authorÇelebi, Melissa
dc.contributor.authorKorkmaz, Ertan Mahir
dc.contributor.authorBaşıbüyük, Hasan Hüseyin
dc.date.accessioned2024-03-08T12:21:08Z
dc.date.available2024-03-08T12:21:08Z
dc.date.issued2023tr
dc.departmentFen Fakültesitr
dc.description.abstractThe animal mitogenomes which undergone a reductive evolution has an obvious loss of coding capacity compared to their known closest relatives, but it has not yet been fully investigated why and how the intergenic regions do not encode protein and have no known functions, are stably maintained, replicated, and transmitted by the genome. These relatively small intergenic regions may not be under neutral evolution and they may have functional and/or regulatory roles that have yet to be identified. Here, the distribution pattern, sequence content and location of a novel sequence motif of ‘WWWGHTW’ were bioinformatically investigated and characterised by constructing a sampling mitogenome dataset of 1889 species from 14 phyla representing the clade of Bilateria. This motif is reverse complementary of the previously described DmTTF binding sequence and found in the nd4L- (X) -trnT gene cluster. This cluster commonly exhibits a strand displacement region and an intergenic region among the bilaterian superphylums, particularly in Ecdysozoa. This motif may be accepted as a substrate providing binding sites for the specific interaction with transcription factors because of (i) its reverse complementarity of previously described DmTTF binding sequence, and (ii) the possession of G and T nucleotides in the fourth and sixth positions, (iii) the bias on T and G nucleotides instead of C and A in the degenerated positions. This suggestion is also supported by the presence of a strand displacement region in the nd4L- (X) -trnT gene cluster, particularly in Ecdysozoa consisting of the most rearranged mitogenomes among the bilaterian superphylums.tr
dc.identifier.citationAydemir, M. N., Aydemir, H. B., Budak, M., Kızıltepe, B., Çelebi, M. Ş., Korkmaz, E. M., & Başıbüyük, H. H. (2023). A novel, conserved and possibly functional motif “WHWGHTW” in mitochondrial transcription across Bilateria. Mitochondrion, 68, 72-80.tr
dc.identifier.doi10.1016/j.mito.2022.11.004en_US
dc.identifier.endpage80tr
dc.identifier.pmid36400160en_US
dc.identifier.scopus2-s2.0-85142722769en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage72tr
dc.identifier.urihttps://doi.org/10.1016/j.mito.2022.11.004
dc.identifier.urihttps://hdl.handle.net/20.500.12418/15095
dc.identifier.volume68tr
dc.identifier.wosWOS:000903717400002en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Başka Kurum Yazarıtr
dc.relation.tubitakTUBİTAK/1001/117Z020
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectMitochondrial transcriptiontr
dc.subjectSignal sequencetr
dc.subjectConserved motiftr
dc.subjectStrand displacementtr
dc.titleA novel, conserved and possibly functional motif “WHWGHTW” in mitochondrial transcription across Bilateriaen_US
dc.typeArticleen_US

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