The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk

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dc.contributor.authorArslan, Sulhattin
dc.contributor.authorKaradayi, Sule
dc.contributor.authorYildirim, Malik Ejder
dc.contributor.authorOzdemir, Ozturk
dc.contributor.authorAkkurt, Ibrahim
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:06:02Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:06:02Z
dc.date.issued2011
dc.department[Karadayi, Sule] Cumhuriyet Univ, Dept Emergency Med, Sch Med, Sivas, Turkey -- [Arslan, Sulhattin -- Akkurt, Ibrahim] Cumhuriyet Univ, Dept Chest Dis, Sch Med, Sivas, Turkey -- [Yildirim, Malik Ejder] Sivas Govt Hosp, Dept Med Genet, Sivas, Turkey -- [Ozdemir, Ozturk] Cumhuriyet Univ, Dept Med Genet, Sch Med, Sivas, Turkeyen_US
dc.description.abstractThis study aimed to determine the relation between methylene-tetrahydrofolate reductase (MTHFR) gene polymorphism and lung cancer risk and the frequency of this polymorphism. The study involved 64 lung cancer patients (the study group) with definitive diagnosis and 61 noncancerous subjects (the control group). MTHFR C677T and A1298C mutation analysis was made using DNA isolated from peripheric blood and multiplex PCR and reverse hybridization strip test. Eighty-four percent of the patients were male. The age, gender, and history of alcohol use of the patients and control group were statistically similar. While MTHFR 677T and 677C allele frequency was 0.33 and 0.67 in the patients respectively, it was 0.29 and 0.71 in the control group. The frequencies of MTHFR 1298C and 1298A were 0.33 and 0.67 in the patients, and it was 0.31 and 0.69 in the control group respectively. When MTHFR 677TT and 677CT genotypes were compared with 677CC genotype, lung cancer risk was 2.4 times higher in the 677TT genotype. When MTHFR 1298AC and 1298CC genotypes were compared with 1298AA genotype, lung cancer risk was 1.5 times higher in 1298CC genotype. According to the results, allele frequency of homozygote T and C was high in lung cancer patients. It was 3.05 and 1.29 times higher in smokers than in non-smokers, and 3.05 and 1.64 times higher in males than in females; 3.0 and 2.44 times higher in those with non-small cell lung cancer than in those with small-cell lung cancer.en_US
dc.identifier.doi10.1007/s11033-010-0194-zen_US
dc.identifier.endpage996en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue2en_US
dc.identifier.pmid20532637en_US
dc.identifier.scopus2-s2.0-79951581547en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage991en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11033-010-0194-z
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9611
dc.identifier.volume38en_US
dc.identifier.wosWOS:000286472600039en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofMOLECULAR BIOLOGY REPORTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethylene-tetrahydrofolate reductaseen_US
dc.subjectAlleleen_US
dc.subjectLung canceren_US
dc.subjectGene polymorphismen_US
dc.titleThe association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risken_US
dc.typeArticleen_US

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