Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study

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dc.authorid0000-0003-3433-8870tr
dc.contributor.authorTas, Ayca
dc.contributor.authorAgbektas, Tugba
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorAydin, Süleyman
dc.contributor.authorHayta, Emrullah
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2024-03-07T07:00:53Z
dc.date.available2024-03-07T07:00:53Z
dc.date.issued2023/12/1tr
dc.departmentYıldızeli Meslek Yüksekokulutr
dc.description.abstractBackground: Fibromyalgia is a soft tissue rheumatism characterized by chronic and widespread musculoskeletal pain at specific points in the body. Objectives: In this study, we aimed to investigate the relationship between Early Growth Response (EGR1, EGR2, and EGR3) protein levels in patients with Fibromyalgia Syndrome (FMS) and healthy controls. Methods: In our studies, 76 FMS patient group and 78 healthy control group who were newly diagnosed with primary FMS according to the 2010 American College of Rheumatology criteria for fibromyalgia in Sivas Cumhuriyet University Hospital, Physical Therapy, and Rehabilitation were used. Venous blood samples were taken from both groups for the measurement of EGR1, EGR2, and EGR3 protein plasma levels, and protein levels were determined using ELISA methods. Statistical parametric test assumptions were compared using the Independent Student's t-test. In addition, specificity, sensitivity, and AUC values were calculated with the ROC curve. Results: The relationship between plasma EGR1 protein levels of FMS patients and control groups was statistically significant (p=0.001). Conclusion: EGR1 protein levels were found to be lower in the patient group diagnosed with FMS compared to the control group. It has been suggested that EGR1 protein levels can be important in the diagnosis of FMS disease.tr
dc.identifier.doi10.2174/0109298665256584231103113328en_US
dc.identifier.endpage1008tr
dc.identifier.issn0929-8665
dc.identifier.issue12tr
dc.identifier.pmid38008944en_US
dc.identifier.scopus2-s2.0-85180856267en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1001tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14842
dc.identifier.volume30tr
dc.identifier.wosWOS:001151260900001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publisherstr
dc.relation.ispartofProtein and Peptide Lettersen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/closedAccesstr
dc.subjectELISAtr
dc.subjectEarly growth response proteinstr
dc.subjectfibromyalgiatr
dc.subjectmusculoskeletal paintr
dc.subjectsoft tissue rheumatismtr
dc.titleInvestigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Studyen_US
dc.typeArticleen_US

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