Synthesis of Bis-Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activities

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dc.authoridhttps://orcid.org/0000-0002-8058-0994tr
dc.authoridhttps://orcid.org/0000-0003-3602-7400tr
dc.contributor.authorTutar, Uğur
dc.contributor.authorGezegen, Hayreddin
dc.date.accessioned2024-03-08T11:47:30Z
dc.date.available2024-03-08T11:47:30Z
dc.date.issued02.10.2023tr
dc.departmentSağlık Bilimleri Fakültesitr
dc.description.abstractIn this study aimed to the synthesis of novel bis-nicotinonitrile derivatives starting from 1,3-bis-chalcones and investigate their antimicrobial activity potentials. Bis-nicotinonitrile derivatives were synthesized from 1,3-bis-chalcone derivatives reacted with malononitrile in ethanol in the presence of potassium carbonate. Characterization of the obtained compounds was carried out by spectroscopic methods. In total, 12 new 1,3- phenylene-bis-nicotinonitrile derivatives were synthesized. Finally, the antimicrobial and antibiofilm activities of synthesized 1,3-phenylene-bis-nicotinonitrile derivatives were tested against 5 microorganisms. As a result, it was observed that the synthesized new nicotinonitrile derivatives were quite active especially in terms of antibiofilm activity.tr
dc.identifier.scopus2-s2.0-85173753749en_US
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12418/15083
dc.identifier.wosWOS:001074815900001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/restrictedAccesstr
dc.subjectAntibiofilm · Antifungal · Antimicrobial · 1,3-Bischalcone · Nicotinonitriletr
dc.titleSynthesis of Bis-Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activitiesen_US
dc.typeArticleen_US

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