The Association of MCP-1 Level and MCP-1 -2518 A/G and CCR2 190 G/A Gene Polymorphisms with COPD and Pulmonary Hypertension

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dc.contributor.authorYildirim, Malik Ejder
dc.contributor.authorBerk, Serdar
dc.contributor.authorKurtulgan, Hande Kucuk
dc.contributor.authorTekin, Gulacan
dc.contributor.authorTekin, Yusuf Kenan
dc.contributor.authorBaser, Burak
dc.contributor.authorBagci, Gokhan
dc.date.accessioned2024-10-26T18:07:17Z
dc.date.available2024-10-26T18:07:17Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by obstructed airflow in the lungs. Pulmonary hypertension (PH) is a common complication of COPD and it is associated with pulmonary vascular remodelling. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines associated with migration of monocytes and macrophages. Both MCP-1 and its receptor CCR2 have been declared to be involved in various diseases. We aimed to research a possible association of MCP-1 level, MCP-1-2518 A/G and CCR2 190 A/G polymorphisms with COPD and pulmonary hypertension in this study. Material and methods: Eighty patients and eighty controls were included in the study. Serum MCP-1 levels were measured by ELISA method. Restriction fragment length polymorphism (RFLP) procedure was used to detect the genotypes of patients and control group. Results: MCP-1 levels were found to be significantly higher in COPD patients than in healthy controls (P=0.001) and patients with COPD + PH had higher serum MCP-1 levels than COPD patients (P=0.005). No association was found between MCP-1/CCR2 gene polymorphisms and patient groups (COPD and COPD + PH). Conclusion: MCP-1 level seems to be associated with both COPD and pulmonary hypertension. Increased MCP-1 expression may most likely to be involved in the pathogenesis of these diseases.
dc.identifier.doi10.12996/gmj.2021.06
dc.identifier.endpage32
dc.identifier.issn2147-2092
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85098655614
dc.identifier.scopusqualityQ4
dc.identifier.startpage28
dc.identifier.urihttps://doi.org/10.12996/gmj.2021.06
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29436
dc.identifier.volume32
dc.identifier.wosWOS:000600546000006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGazi Univ, Fac Med
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMCP-1
dc.subjectCCR2
dc.subjectCOPD
dc.subjectpulmonary hypertension
dc.subjectpolymorphism
dc.titleThe Association of MCP-1 Level and MCP-1 -2518 A/G and CCR2 190 G/A Gene Polymorphisms with COPD and Pulmonary Hypertension
dc.typeArticle

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