Investigating the Effects of Systemically Administered Strontium Ranelate on Alveolar Bone Loss Histomorphometrically and Histopathologically on Experimental Periodontitis in Rats

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dc.contributor.authorKarakan, Nebi Cansin
dc.contributor.authorAkpinar, Aysun
dc.contributor.authorGoze, Fahrettin
dc.contributor.authorPoyraz, Omer
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:01Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:01Z
dc.date.issued2017
dc.department[Karakan, Nebi Cansin -- Akpinar, Aysun] Cumhuriyet Univ, Dept Periodontol, Fac Dent, TR-58100 Sivas, Turkey -- [Goze, Fahrettin] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- [Poyraz, Omer] Cumhuriyet Univ, Fac Med, Dept Microbiol, Sivas, Turkeyen_US
dc.description.abstractBackground: The aim of this study is to investigate effects of strontium ranelate (SR) on alveolar bone loss (ABL) in rats with experimental periodontitis. Methods: Forty Wistar rats were randomly divided into five groups: 1) control (n = 8); 2) ligated (n = 8); 3) 300 mg/kg SR (SR300, n = 8); 4) 625 mg/kg SR (SR625, n = 8); and 5) 900 mg/kg SR (SR900, n = 8). To create experimental periodontitis, 4/0 silk ligatures were inserted submarginally around first molars at the right mandible. After 11 days, rats were sacrificed. ABL was calculated by measuring cemento-enamel junction and alveolar crest distance. Interleukin (IL)-1 beta, osteoprotegerin (OPG), and bone-specific alkaline phosphatase (BALP) serum levels were determined by enzyme-linked immunosorbent assay. Histopathologic analysis was used to evaluate inflammatory cell infiltration, numbers of osteoblasts and osteoclasts, and receptor activator of nuclear factor-kappa B ligand (RANKL) activity. Results: ABL was significantly lower in SR900 group than in the ligated group (P <0.05). Osteoclast numbers in ligated group were significantly higher than in the control, SR300, and SR900 groups (P < 0.05). In ligated, SR625, and SR900 groups, significantly higher osteoblast numbers were detected than in control group (P < 0.05). Osteoblast numbers in SR625 group were significantly higher than in the SR300 group (P <0.05). RANKL activities in SR900 and control groups were close to each other (P >0.05). Serum IL- 1 beta, OPG, and BALP levels revealed no significant difference (P >0.05). Conclusion: It can be concluded that SR can reduce RANKL activity and osteoclast numbers, as well as ABL.en_US
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University [Disx 141]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Project Fund of Cumhuriyet University under the project number Disx 141 (to Aysun Akpinar). The authors also thank Dr. Ziynet Cxinar (Cumhuriyet University, Faculty of Medicine, Department of Biostatistics, Sivas, Turkey). The authors report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1902/jop.2016.160227en_US
dc.identifier.endpageE31en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue2en_US
dc.identifier.pmid27615270en_US
dc.identifier.scopus2-s2.0-85011977357en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpageE24en_US
dc.identifier.urihttps://dx.doi.org/10.1902/jop.2016.160227
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6857
dc.identifier.volume88en_US
dc.identifier.wosWOS:000394509300001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER ACAD PERIODONTOLOGYen_US
dc.relation.ispartofJOURNAL OF PERIODONTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteoblastsen_US
dc.subjectosteoclastsen_US
dc.subjectpathologyen_US
dc.subjectperiodontal diseasesen_US
dc.subjectperiodontitisen_US
dc.subjectstrontiumen_US
dc.titleInvestigating the Effects of Systemically Administered Strontium Ranelate on Alveolar Bone Loss Histomorphometrically and Histopathologically on Experimental Periodontitis in Ratsen_US
dc.typeArticleen_US

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