Effect of taxifolin on acrylamide-induced oxidative and proinflammatory lung injury in rats: Biochemical and histopathological studies

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dc.authoridDemir, Omer Faruk/0000-0001-8380-9312
dc.contributor.authorDemir, Omer Faruk
dc.contributor.authorElma, Bekir
dc.contributor.authorSuleyman, Bahadir
dc.contributor.authorOzkaraca, Mustafa
dc.contributor.authorMammadov, Renad
dc.contributor.authorSuleyman, Halis
dc.contributor.authorCoban, Taha Abdulkadir
dc.date.accessioned2024-10-26T18:09:04Z
dc.date.available2024-10-26T18:09:04Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: To examine the probable beneficial effects of taxifolin against acrylamide damage in lung tissue. Methods: 18 male albino Wistar rats were divided into healthy (HG), acrylamide (AG) and taxifolin + acrylamide (TAG) groups. Once a day for 30 days, acrylamide was orally administered to the AG group (50 mg/kg), while ACL (50 mg/kg) and TAX (20 mg/kg) were orally administered to TAG group. Protein concentration, malondialdehyde (MDA), and total glutathione (tGSH) levels as well as oxidant and antioxidant molecules concentrations of the rat lung tissues were measured. In addition, degree of mononuclear (MN) cell infiltration and bronchial-associated lymphoid tissue (BALT) hyperplasia was evaluated by the degree of hyperplasia (absent, mild, moderate, severe). The histopathological and biochemical data the groups were compared. Results: When compared in terms of MDA levels, it was found that the AG group had high MDA levels, and the TAG group had low MDA levels. (p < 0.001). TAG group was found to have a higher tGSH level than the AG group (p < 0.001). Compared to the AG group, lower TOS and higher TAS levels were obtained in the TAG group (p < 0.001). In addition, when TOS levels of TAG and HG groups were compared, the TOS levels between the two groups were statistically insignificant (p = 0.213). It has been observed that TAX administration prevents the increase in NF-KB level. When the NF-KB levels of the AG and TAG groups were compared with each other, there was a statistically significant difference (p = 0.001). In the AG group, severe MN cell hyperplasia and BALT hyperplasia were observed histopathologically. It was determined that these findings were alleviated in the TAG group. A histopathologically significant difference was found between AG and TAG groups (p < 0.05). Conclusion: Taxifolin has beneficial effects against lung injury caused by acrylamide, a health damaging environmental factor. Regular use of taxifolin can be recommended, especially in people who are known to have intense contact with acrylamide. There is a need for research studies on this subject.
dc.identifier.doi10.4314/tjpr.v21i5.10
dc.identifier.endpage979
dc.identifier.issn1596-5996
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85133724179
dc.identifier.scopusqualityQ3
dc.identifier.startpage973
dc.identifier.urihttps://doi.org/10.4314/tjpr.v21i5.10
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29939
dc.identifier.volume21
dc.identifier.wosWOS:000807432200010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPharmacotherapy Group
dc.relation.ispartofTropical Journal of Pharmaceutical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcrylamide
dc.subjectTaxifolin
dc.subjectLung injury
dc.subjectOxidative stress
dc.subjectInflammatory response
dc.titleEffect of taxifolin on acrylamide-induced oxidative and proinflammatory lung injury in rats: Biochemical and histopathological studies
dc.typeArticle

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