Evaluation of the Anticancer and Biological Activities of Istaroxime via Ex Vivo Analyses, Molecular Docking and Conceptual Density Functional Theory Computations
| dc.authorid | 0000-0001-8623-784X | tr |
| dc.contributor.author | Canturk, Pakize | |
| dc.contributor.author | Gok, Ege | |
| dc.contributor.author | Unal, Naz | |
| dc.contributor.author | Gungor, Burcin | |
| dc.contributor.author | Karakus, Gulderen | |
| dc.contributor.author | Kaya, Savas | |
| dc.contributor.author | Katin, Konstantin P. | |
| dc.date.accessioned | 2024-02-26T07:37:46Z | |
| dc.date.available | 2024-02-26T07:37:46Z | |
| dc.date.issued | 7 November 2023 | tr |
| dc.department | Eczacılık Fakültesi | tr |
| dc.description.abstract | Cancer is a disease that occurs as a result of abnormal or uncontrolled growth of cells due to DNA damage, among many other causes. Certain cancer treatments aim to increase the excess of DNA breaks to such an extent that they cannot escape from the general mechanism of cell checkpoints, leading to the apoptosis of mutant cells. In this study, one of the Sarco-endoplasmic reticulum Ca2+ATPase (SERCA2a) inhibitors, Istaroxime, was investigated. There has been very limited number of articles so far reporting Istaroxime’s anticancer activity; thus, we aimed to evaluate the anticancer effects of Istaroxime by cell proliferation assay and revealed the cytotoxic activity of the compound. We further determined the interaction of Istaroxime with topoisomerase enzymes through enzyme activity tests and detailed molecular modeling analysis. Istaroxime exhibited an antiproliferative effect on A549, MCF7, and PC3 cell lines and inhibited Topoisomerase I, suggesting that Istaroxime can act as a Topoisomerase I inhibitor under in vitro conditions. Molecular docking analysis supported the experimental observations. A chemical reactivity analysis of the Istaroxime molecule was made in the light of Density Functional Theory computations. For this aim, important chemical reactivity descriptors such as hardness, electronegativity, and electrophilicity were computed and discussed as detailed. | tr |
| dc.description.sponsorship | TÜBİTAK-BİDEP2209A | tr |
| dc.identifier.citation | Export citation file: BibTeX | EndNote | RIS MDPI and ACS Style Gok, E.; Unal, N.; Gungor, B.; Karakus, G.; Kaya, S.; Canturk, P.; Katin, K.P. Evaluation of the Anticancer and Biological Activities of Istaroxime via Ex Vivo Analyses, Molecular Docking and Conceptual Density Functional Theory Computations. Molecules 2023, 28, 7458. https://doi.org/10.3390/molecules28227458 AMA Style Gok E, Unal N, Gungor B, Karakus G, Kaya S, Canturk P, Katin KP. Evaluation of the Anticancer and Biological Activities of Istaroxime via Ex Vivo Analyses, Molecular Docking and Conceptual Density Functional Theory Computations. Molecules. 2023; 28(22):7458. https://doi.org/10.3390/molecules28227458 Chicago/Turabian Style Gok, Ege, Naz Unal, Burcin Gungor, Gulderen Karakus, Savas Kaya, Pakize Canturk, and Konstantin P. Katin. 2023. "Evaluation of the Anticancer and Biological Activities of Istaroxime via Ex Vivo Analyses, Molecular Docking and Conceptual Density Functional Theory Computations" Molecules 28, no. 22: 7458. https://doi.org/10.3390/molecules28227458 | tr |
| dc.identifier.doi | 10.3390/molecules28227458 | en_US |
| dc.identifier.endpage | 7458 | tr |
| dc.identifier.issue | 22 | tr |
| dc.identifier.pmid | 38005181 | en_US |
| dc.identifier.scopus | 2-s2.0-85177742077 | en_US |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 7458 | tr |
| dc.identifier.uri | https://www.mdpi.com/1420-3049/28/22/7458 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/14311 | |
| dc.identifier.volume | 28 | tr |
| dc.identifier.wos | WOS:001113726800001 | en_US |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | MDPI | tr |
| dc.relation.ispartof | Molecules | en_US |
| dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale | tr |
| dc.relation.tubitak | BİDEP2209A-1919B011701733 | |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.subject | Istaroxime; Topoisomerase enzymes; Anticancer drugs; Density Functional Theory | tr |
| dc.title | Evaluation of the Anticancer and Biological Activities of Istaroxime via Ex Vivo Analyses, Molecular Docking and Conceptual Density Functional Theory Computations | en_US |
| dc.type | Article | en_US |
