New water soluble magnesium phthalocyanine as a potential anticancer drug: Cytotoxic and apoptotic effect on different cancer cell lines
| dc.authorid | 0000-0001-7163-3057 | tr |
| dc.contributor.author | Ebru YABAŞ | |
| dc.contributor.author | Serap Şahin Bölükbaşı | |
| dc.contributor.author | Zeynep Deniz Şahin İnan | |
| dc.date.accessioned | 2023-04-12T08:47:17Z | |
| dc.date.available | 2023-04-12T08:47:17Z | |
| dc.date.issued | 2022 | tr |
| dc.department | İmranlı Meslek Yüksekokulu | tr |
| dc.description.abstract | Although phthalocyanines are usually used a photosensitizers for photodynamic therapy, these works focus on the directly cytotoxic effect of a new water-soluble magnesium phthalocyanine. The new water-soluble magnesium phthalocyanine 2 was synthesized, characterized and investigated for cytotoxic and apoptotic activities. The cytotoxic activities of the compound 2 were determined by using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability assay on human breast cancer cells (MDA-MB-231, MCF-7), human prostate cancer cells (PC-3), and human healthy lung fibroblast cells (WI-38). The cells were plated and treated 1 to 20 mM of different concentrations of the compound. MTT assay results indicated that the compound 2 has concentration and time-dependent cytotoxic activities against cancer cells. We also observed that the compound displayed lower toxicity against WI-38 healthy cells than cancer cells at 48 and 72 h. The compound showed a significant cytotoxic activity difference between breast cancer cells and WI-38 healthy cells at 48 and 72 h. Selectivity index of the compound 2 against MCF-7 for 72 h was calculated >15.62. We also studied the apoptotic and necrotic effect of compound 2 using TUNEL and PI staining, respectively. It was found that the synthesized compound 2 increased apoptotic and necrotic cells. | tr |
| dc.identifier.scopus | 2-s2.0-85113814190 | en_US |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/13638 | |
| dc.identifier.wos | WOS:000735346100007 | en_US |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.language.iso | en | en_US |
| dc.relation.publicationcategory | Rapor | tr |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.title | New water soluble magnesium phthalocyanine as a potential anticancer drug: Cytotoxic and apoptotic effect on different cancer cell lines | en_US |
| dc.type | Animation | en_US |
