In Silico and In Vitro Antiproliferative Activity Assessment of New Schiff Bases

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dc.authoridAkkoc, Senem/0000-0002-1260-9425
dc.authoridKARATAS, Halis/0000-0001-5473-5588
dc.contributor.authorKokbudak, Zulbiye
dc.contributor.authorAkkoc, Senem
dc.contributor.authorKaratas, Halis
dc.contributor.authorTuzun, Burak
dc.contributor.authorAslan, Guezin
dc.date.accessioned2024-10-26T18:07:43Z
dc.date.available2024-10-26T18:07:43Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study, a series of new Schiff bases, based on a pyrimidine core, were synthesized in two steps. The structures of these newly synthesized Schiff bases were completely characterized. The presence of characteristic -N=CH proton peaks proving the formation of imine supports the structures of the compounds. The cytotoxic activity studies were done towards human cancer cell lines. The results show that the related molecules had antiproliferative activity on cancerous cells. To compare the chemical and biological activities of pyrimidine derivatives were performed using Gaussian software and Maestro Molecular modeling platform by Schrodinger, respectively. Afterwards, ADME/T analysis was performed to examine the possibility of pyrimidine derivatives being drugs.
dc.description.sponsorshipErciyes University [FBA-2019-8639]; Suleyman Demirel University [TSG-2021-8458]
dc.description.sponsorshipWe want to thank Erciyes University Research Fund (FBA-2019-8639) for their financial support. Also, SA would like to thank Suleyman Demirel University Research Fund for financial support with project number TSG-2021-8458.
dc.identifier.doi10.1002/slct.202103679
dc.identifier.issn2365-6549
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85124098991
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/slct.202103679
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29657
dc.identifier.volume7
dc.identifier.wosWOS:001030696100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCancer
dc.subjectCytotoxicity
dc.subjectMolecular docking
dc.subjectPyrimidine
dc.subjectSchiff base
dc.titleIn Silico and In Vitro Antiproliferative Activity Assessment of New Schiff Bases
dc.typeArticle

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