Syringic acid guards against indomethacin-induced gastric ulcer by alleviating inflammation, oxidative stress and apoptosis

Basit Öğe Kaydı
dc.contributor.authorOkkay, Irmak Ferah
dc.contributor.authorOkkay, Ufuk
dc.contributor.authorCicek, Betul
dc.contributor.authorKaratas, Ozhan
dc.contributor.authorYilmaz, Aysegul
dc.contributor.authorYesilyurt, Fatma
dc.contributor.authorHacimuftuoglu, Ahmet
dc.date.accessioned2024-10-26T18:09:14Z
dc.date.available2024-10-26T18:09:14Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe purpose of this study was to evaluate the effects of syringic acid, an anti-oxidant, on indomethacin induced gastric ulcers in rats. Experimental groups were control, ulcer, ulcer treated with 20 mg/kg esomeprazole (a proton pump inhibitor that reduces acid secretion), and ulcer treated with 100 mg/kg syringic acid. Rats were pretreated with esomeprazole or syringic acid two weeks before ulcer induction. Our histopathological observations showed that either syringic acid or esomeprazole attenuated the severity of gastric mucosal damage. Moreover, syringic acid and esomeprazole pretreatments alleviated indomethacin-induced damage by regulating oxidative stress, inflammatory response, the level of transforming growth factor-beta (TGF-beta), expressions of COX and prostaglandin E2, cell proliferation, apoptosis and regulation of the NF-kappa B signaling pathway. We conclude that either esomeprazole or syringic acid administration protected the gastric mucosa from harmful effects of indomethacin. Syringic acid might, therefore be a potential therapeutic agent for preventing and treating indomethacin-induced gastric damage.
dc.identifier.doi10.1080/10520295.2024.2344477
dc.identifier.endpage156
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3
dc.identifier.pmid38644776
dc.identifier.scopus2-s2.0-85191183698
dc.identifier.scopusqualityQ2
dc.identifier.startpage147
dc.identifier.urihttps://doi.org/10.1080/10520295.2024.2344477
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30019
dc.identifier.volume99
dc.identifier.wosWOS:001207014300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGastric ulcer
dc.subjectindomethacin
dc.subjectNF-kappa B
dc.subjectoxidative stress
dc.subjectsyringic acid
dc.titleSyringic acid guards against indomethacin-induced gastric ulcer by alleviating inflammation, oxidative stress and apoptosis
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu