Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep
| dc.authorid | 0000-0002-2506-3855 | tr |
| dc.contributor.author | Hüseyin GÜNGÖR | |
| dc.contributor.author | Orhan ÇORUM | |
| dc.contributor.author | Duygu Durna ÇORUM | |
| dc.contributor.author | Alper Serhat KUMRU | |
| dc.contributor.author | Gökhan YILMAZ | |
| dc.contributor.author | Devran COŞKUN | |
| dc.contributor.author | Alparslan COŞKUN | |
| dc.contributor.author | Kamil ÜNEY | |
| dc.date.accessioned | 2024-02-29T13:30:26Z | |
| dc.date.available | 2024-02-29T13:30:26Z | |
| dc.date.issued | 13/09/2023 | tr |
| dc.department | Veteriner Fakültesi | tr |
| dc.description.abstract | The aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was administered intravenously to each sheep at 0.5, 1, and 2 mg/kg doses in a longitudinal pharmacokinetic design with a 15-day washout period. Plasma concentrations of meloxicam were determined using the high performance liquid chromatography-ultraviolet, and pharmacokinetic parameters were evaluated by non-compartmental analysis. Meloxicam was detected up to 48 h in the 0.5 mg/kg dose and up to 96 h in the 1 and 2 mg/kg doses. As the dose increased from 0.5 to 2 mg/kg, terminal elimination half-life, and dose normalized area under the concentration versus time curve increased and total clearance decreased. Compared to the 1 mg/kg dose, it was determined that Vdss decreased and C0.083h increased in the 2 mg/kg dose. Meloxicam provided the therapeutic concentration of >0.39 μg/mL reported in other species for 12, 48 and 96 h at 0.5, 1 and 2 mg/kg doses, respectively. These results show that meloxicam exhibits non-linear pharmacokinetics and will achieve unpredictable plasma concentrations when administered IV for a rapid effect at dose of ≥1 mg/kg in sheep. | tr |
| dc.identifier.doi | 10.1111/jvp.13422 | en_US |
| dc.identifier.pmid | 38033195 | en_US |
| dc.identifier.scopus | 2-s2.0-85178223399 | en_US |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/14489 | |
| dc.identifier.wos | WOS:001111260300001 | en_US |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.language.iso | en | en_US |
| dc.relation.publicationcategory | Rapor | tr |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.subject | increasing dose, meloxicam, pharmacokinetics, sheep | tr |
| dc.title | Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep | en_US |
| dc.type | Article | en_US |
