Atrial fibrillation is associated with increased mean platelet volume in patients with type 2 diabetes mellitus

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dc.authoridTurgut, Okan -- 0000-0002-6847-3029en_US
dc.contributor.authorTurgut, Okan
dc.contributor.authorZorlu, Ali
dc.contributor.authorKilicli, Fatih
dc.contributor.authorCinar, Ziynet
dc.contributor.authorYucel, Hasan
dc.contributor.authorTandogan, Izzet
dc.contributor.authorDokmetas, Hatice Sebila
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:07Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:07Z
dc.date.issued2013
dc.department[Turgut, Okan -- Zorlu, Ali -- Yucel, Hasan -- Tandogan, Izzet] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Kilicli, Fatih -- Dokmetas, Hatice Sebila] Cumhuriyet Univ, Fac Med, Dept Internal Med, Div Endocrinol & Metab, TR-58140 Sivas, Turkey -- [Cinar, Ziynet] Cumhuriyet Univ, Fac Med, Dept Biostat, TR-58140 Sivas, Turkeyen_US
dc.description.abstractPlatelet abnormalities in diabetes mellitus (DM) and atrial fibrillation (AF) may underline the etiology of a prothrombotic state in these conditions. Increased mean platelet volume (MPV) is a marker of abnormal platelet function and activation. We aimed to investigate the possible association of chronic AF with MPV in patients who have type 2 DM. Patients who had type 2 DM with either chronic (>= 6 months) AF or normal sinus rhythm (NSR) were included in the study. A total of 162 patients (aged 38-89 years) were divided into 2 groups according to the presence of either AF or NSR. Group 1 consisted of 81 diabetic patients with AF, and group 2 consisted of 81 diabetic patients with NSR. The two groups were not significantly different in terms of age, and gender, as well as in hypertension, smoking, history of coronary artery disease, previous cerebrovascular accidents, microalbuminuria, retinopathy, duration of DM, body mass index, hemoglobin A(1c), total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride (p > 0.05 for all variables). Although no significant difference was present between groups concerning platelet count; for patients with AF, MPV was higher compared with patients with NSR (9.0 +/- 0.2 fl vs. 8.4 +/- 0.2 fl; p = 0.001). Furthermore, no significant difference was noted between groups regarding routine medications received by patients. In multivariate logistic regression analysis, MPV was the only variable independently related to AF (OR = 2.659; 95% CI, 1.286-5.498; p = 0.008). Consequently, it is concluded that AF is associated with increased MPV in patients with type 2 DM, suggesting the presence of tentatively related processes leading to reciprocal interaction.en_US
dc.identifier.doi10.3109/09537104.2012.725876en_US
dc.identifier.endpage497en_US
dc.identifier.issn0953-7104
dc.identifier.issn1369-1635
dc.identifier.issue6en_US
dc.identifier.pmid22994845en_US
dc.identifier.scopus2-s2.0-84880863244en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage493en_US
dc.identifier.urihttps://dx.doi.org/10.3109/09537104.2012.725876
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8867
dc.identifier.volume24en_US
dc.identifier.wosWOS:000322171400012en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofPLATELETSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtrial fibrillationen_US
dc.subjectdiabetes mellitusen_US
dc.subjectmean platelet volumeen_US
dc.titleAtrial fibrillation is associated with increased mean platelet volume in patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US

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