Cardioprotective Effect of Empagliflozin in Rats with IsoproterenolInduced Myocardial Infarction: Evaluation of Lipid Profile, Oxidative Stress, Inflammation, DNA Damage, and Apoptosis

Ekici, Mehmet; Güngör, Hüseyin; Karayiğit, Mehmet Önder; Turgut, Nergiz Hacer; Koçkaya, Mustafa; Karataş, Özhan; Üner, Aykut Göktürk

Cardioprotective Effect of Empagliflozin in Rats with IsoproterenolInduced Myocardial Infarction: Evaluation of Lipid Profile, Oxidative Stress, Inflammation, DNA Damage, and Apoptosis

dc.authorid	0000-0002-2163-6214	tr
dc.authorid	0000-0002-2506-3855	tr
dc.authorid	0000-0002-7958-180X	tr
dc.authorid	0000-0001-5705-2475	tr
dc.authorid	0000-0001-5173-0853	tr
dc.authorid	0000-0002-2778-8059	tr
dc.authorid	0000-0002-9242-8279	tr
dc.contributor.author	Ekici, Mehmet
dc.contributor.author	Güngör, Hüseyin
dc.contributor.author	Karayiğit, Mehmet Önder
dc.contributor.author	Turgut, Nergiz Hacer
dc.contributor.author	Koçkaya, Mustafa
dc.contributor.author	Karataş, Özhan
dc.contributor.author	Üner, Aykut Göktürk
dc.date.accessioned	2023-06-22T12:05:13Z
dc.date.available	2023-06-22T12:05:13Z
dc.date.issued	2022-11-13	tr
dc.department	Veteriner Fakültesi	tr
dc.description.abstract	—The antidiabetic drug empagliflozin is reported to have many cardioprotective effects. However, no studies have investigated the protective effects of empagliflozin (EMPA) in isoprenaline (ISO)-induced cardiac oxidative damage-a model mimicking the harmful effects of excess catecholamines on the heart. Therefore, in this study, we aimed to reveal the protective effect of EMPA in isoproterenol ISO-induced myocardial infarction in rats. We induced myocardial infarction by subcutaneously injecting ISO (100 mg/kg). To determine the protective effects of EMPA on the myocardial damage, we administered two different doses (10 and 20 mg/kg) by gavage for 14 days. Here we have shown that a 20 mg/kg dose of EMPA completely rescues rats from myocardial infarction by normalizing the following: elevated ST-segment, increased heart rate, decreased R amplitude, prolongation of the QT interval, and shortened RR interval. In addition, EMPA (20 mg/kg) ameliorates ISO-induced changes in serum cTnI, CK, ischemia-modified albumin (IMA), LDH, AST, ALT levels, and heart index. It improves serum lipid profile by decreasing cholesterol, triglycerides, LDL, and VLDL levels, and by increasing HDL levels. Moreover, EMPA (20 mg/kg) alleviates increased myocardial oxidative stress and inflammation by decreasing MDA, TNF-α, and IL-6 levels and increasing SOD and GPx levels. Furthermore, 20 mg/kg EMPA leads to reductions in DNA damage and apoptosis by downregulating of 8-OHdG and caspase-3 expressions. Collectively, EMPA exerts its protective effects on myocardial damage by improving oxidative stress, apoptosis, lipid profile and oxidative DNA damage in ISO-induced experimental myocardial infarction in rats.	tr
dc.identifier.doi	10.1134/s1062359022130039	en_US
dc.identifier.endpage	172	tr
dc.identifier.issue	6	tr
dc.identifier.scopus	2-s2.0-85141045905	en_US
dc.identifier.scopusquality	N/A
dc.identifier.startpage	159	tr
dc.identifier.uri	https://link.springer.com/article/10.1134/S1062359022130039
dc.identifier.uri	https://hdl.handle.net/20.500.12418/13966
dc.identifier.volume	49	tr
dc.identifier.wos	WOS:000877468400017	en_US
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science	en_US
dc.indekslendigikaynak	Scopus	en_US
dc.language.iso	en	en_US
dc.publisher	PLEIADES PUBLISHING INC	tr
dc.relation.ispartof	BIOLOGY BULLETIN	en_US
dc.relation.publicationcategory	Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı	tr
dc.rights	info:eu-repo/semantics/openAccess	tr
dc.subject	apoptosis, DNA damage, empagliflozin, inflammation, isoproterenol, oxidative stress	tr
dc.title	Cardioprotective Effect of Empagliflozin in Rats with IsoproterenolInduced Myocardial Infarction: Evaluation of Lipid Profile, Oxidative Stress, Inflammation, DNA Damage, and Apoptosis	en_US
dc.type	Article	en_US