Comparison of lipemia interference created with native lipemic material and intravenous lipid emulsion in emergency laboratory tests

Basit Öğe Kaydı
dc.authoridCOLAK SAMSUM, EMEL/0000-0002-7701-1379
dc.contributor.authorSamsum, Emel Colak
dc.contributor.authorSurer, Hatice
dc.contributor.authorBolat, Serkan
dc.contributor.authorSenes, Mehmet
dc.contributor.authorYucel, Dogan
dc.date.accessioned2024-10-26T18:09:40Z
dc.date.available2024-10-26T18:09:40Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: This study aimed to investigate the effects of lipemia on clinical chemistry and coagulation parameters in native ultralipemic (NULM) and intravenous lipid emulsion (IVLE) spiked samples. Materials and methods: The evaluation of biochemistry (photometric, ion-selective electrode, immunoturbidimetric method), cardiac (electrochemiluminescence immunoassay method) and coagulation (the viscosity-based mechanical method for prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen and the immunoturbidimetric method for D-dimer) parameters were conducted. In addition to the main pools, five pools were prepared for both types of lipemia, each with triglyceride (TG) concentrations of approximately 2.8, 5.7, 11.3, 17.0 and 22.6 mmol/L. All parameters' mean differences (MD%) were presented as interferographs and compared with the desirable specification for the inaccu Results: Prothrombin time and APTT showed no clinically relevant interference in IVLE-added pools but were negatively affected in NULM pools (P < 0.001 in both parameters). For biochemistry, the most striking difference was seen for CRP; it is up to 134 MD% value with NULM (P < 0.001) at the highest TG concentration, whereas it was up to - 2.49 MD% value with IVLE (P = 0.009). Albumin was affected negatively upward of 5.7 mmol/L TG with IVLE, while there was no effect for NULM. Creatinine displayed significant positive interferences with NULM starting at the lowest TG concentration (P = 0.028). There was no clinically relevant interference in cardiac markers for both lipemia types. Conclusions: Significant differences were scrutinized in interference patterns of lipemia types, emphasizing the need for careful consideration of lipemia interferences in clinical laboratories. It is crucial to note that lipid emulsions inadequately replicate lipemic samples.
dc.identifier.doi10.11613/BM.2024.020701
dc.identifier.issn1330-0962
dc.identifier.issn1846-7482
dc.identifier.issue2
dc.identifier.pmid38665874
dc.identifier.scopus2-s2.0-85191505711
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.11613/BM.2024.020701
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30220
dc.identifier.volume34
dc.identifier.wosWOS:001254069100015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCroatian Soc Medical Biochemistry & Laboratory Medicine
dc.relation.ispartofBiochemia Medica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectlipemia
dc.subjectintravenous lipid emulsions
dc.subjectinterference
dc.subjectclinical chemistry tests
dc.subjectpreanalytical phase
dc.titleComparison of lipemia interference created with native lipemic material and intravenous lipid emulsion in emergency laboratory tests
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu