Synthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine-based tripeptides

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dc.authorid0000-0001-6744-929Xtr
dc.contributor.authorÇalışkan Eray
dc.contributor.authorKaplan, A.
dc.contributor.authorŞekerci, G.
dc.contributor.authorÇapan, İ.
dc.contributor.authorTekin, S.
dc.contributor.authorErkan Sultan
dc.contributor.authorKoran Kenan
dc.contributor.authorSandal Süleyman
dc.contributor.authorGörgülü, A. O.
dc.date.accessioned2024-03-07T10:10:38Z
dc.date.available2024-03-07T10:10:38Z
dc.date.issued2023tr
dc.departmentFen Fakültesitr
dc.description.abstractPeptides are one of the leading groups of compounds that have been the subject of a great deal of biological research and still continue to attract researchers' attention. In this study, a series of tripeptides based on tyrosine amino acids were synthesized by the triazine method. The cytotoxicity properties of all compounds against human cancer cell lines (MCF-7), ovarian (A2780), prostate (PC-3), and colon cancer cell lines (Caco-2) were determined by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay method, and % cell viability and logIC50 values of the compounds were calculated. Significant decreases in cell viability were observed in all cells (p < 0.05). The comet assay method was used to understand that the compounds that showed a significant decrease in cell viability had this effect through DNA damage. Most of the compounds exhibited cytotoxicity by DNA damage mechanism. Besides, their interactions between investigated molecule groups with PDB ID: 3VHE, 3C0R, 2ZCL, and 2HQ6 target proteins corresponding to cancer cell lines, respectively, were investigated by docking studies. Finally, molecules with high biological activity against biological receptors were determined by ADME analysis.tr
dc.identifier.citationÇalışkan, E., Kaplan, A., Şekerci, G., Çapan, İ., Tekin, S., Erkan, S., ... & Görgülü, A. O. (2023). Synthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine‐based tripeptides. Journal of Biochemical and Molecular Toxicology, e23388.tr
dc.identifier.doi10.1002/jbt.23388en_US
dc.identifier.issue8tr
dc.identifier.pmid37243846en_US
dc.identifier.scopus2-s2.0-85160815460en_US
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/jbt.23388
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14894
dc.identifier.volume37tr
dc.identifier.wosWOS:000994138400001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileytr
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Başka Kurum Yazarıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectADME, cytotoxicity, DNA damage, molecular docking, peptidestr
dc.titleSynthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine-based tripeptidesen_US
dc.typeArticleen_US

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