Evaluation of Oxidative Stress Levels and Dynamic Thiol-disulfide Balance in Patients with Retinopathy of Prematurity

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dc.authoridTunc, Gaffari/0000-0001-7837-3948
dc.authoridErdal, Huseyin/0000-0003-0786-5077
dc.authoridDemirtas, Mehmet Semih/0000-0003-2965-1811
dc.authoridKilicbay, Fatih/0000-0001-9073-0864
dc.contributor.authorErdal, Huseyin
dc.contributor.authorDemirtas, Mehmet Semih
dc.contributor.authorKilicbay, Fatih
dc.contributor.authorTunc, Gaffari
dc.date.accessioned2024-10-26T18:07:57Z
dc.date.available2024-10-26T18:07:57Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurposeThe aim of this study is to evaluate both dynamic thiol-disulfide homeostasis and oxidative stress (OS) levels in patients with retinopathy of prematurity (ROP).MethodsA total of 129 infants of <34 weeks gestational age were enrolled in the present study. The thiol-disulfide homeostasis was determined by using the new, cost-effective and fully automated colorimetric method. Total antioxidant status (TAS), Total oxidant status (TOS) and Oxidative stress index (OSI) levels were evaluated.ResultsWe found serum TAS levels were lower while serum TOS and OSI levels were significantly higher in patients with ROP compare to the without ROP group (p < .05). However, native, total and disulfide values were not statistically significant between the groups (p > .05). In addition, we also evaluated the native, total and disulfide levels in patients with ROP according to grades and no statistically significant results were found (p > .05). Low birth weight (p = .001), gestational age (p = .001) and 5-min Apgar score were significantly lower in the ROP group.ConclusionThis study revealed that dynamic thiol-disulfide homeostasis was changed in patients with ROP. Increased TOS and decreased TAS levels may be associated with functional reduction of the antioxidant system due to increased OS. This indicate that ROP patients are highly sensitive to OS. The dynamic thiol-disulfide homeostasis may conduce to the pathophysiological mechanism and disease follow-up in patients with ROP. The results of this study show that ROP patients are highly sensitive to oxidative stress.
dc.identifier.doi10.1080/02713683.2023.2185569
dc.identifier.endpage1033
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue11
dc.identifier.pmid36912268
dc.identifier.scopus2-s2.0-85150651374
dc.identifier.scopusqualityQ2
dc.identifier.startpage1026
dc.identifier.urihttps://doi.org/10.1080/02713683.2023.2185569
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29756
dc.identifier.volume48
dc.identifier.wosWOS:000949075100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCurrent Eye Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOxidative stress
dc.subjectretinopathy of prematurity
dc.subjectthiol-disulfide homeostasis
dc.subjectnewborn
dc.subjectoxidants
dc.titleEvaluation of Oxidative Stress Levels and Dynamic Thiol-disulfide Balance in Patients with Retinopathy of Prematurity
dc.typeArticle

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