The proinflammatory cytokine-mediated protective effects of pentoxifylline, iloprost, and cilostazol on a mitigating lung injury induced by lower limb ischemia and reperfusion in rats

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dc.contributor.authorHidiroglu, Mete
dc.contributor.authorUguz, Emrah
dc.contributor.authorOzerdem, Gokhan
dc.contributor.authorYildiz, Esin
dc.contributor.authorBerkan, Ocal
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:58:08Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:58:08Z
dc.date.issued2014
dc.department[Hidiroglu, Mete -- Uguz, Emrah] Ankara Ataturk Egitim & Arastirma Hastanesi, Dept Cardiovasc Surg, TR-06800 Ankara, Turkey -- [Ozerdem, Gokhan] Sevgi Hosp, Dept Cardiovasc Surg, Kayseri, Turkey -- [Yildiz, Esin] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- [Berkan, Ocal] Cumhuriyet Univ, Fac Med, Dept Cardiovasc Surg, Sivas, Turkeyen_US
dc.description.abstractBackground: This study aims to elucidate whether pentoxifylline, iloprost and cilostazol mitigates acute lung injury induced by lower limb ischemia-reperfusion (I/R) and their protective effects cover cytokines. Methods: Forty rats were randomized into five groups: control (group 1), ischemia-reperfusion (group 2), pentoxifylline (group 3), iloprost (group 4), iloprost and cilostazol (group 5). All drugs were administered before ischemia. Samples were obtained for tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and total sialic acid (TSA) assays. Findings of lung injury were examined. Results: Interleukin-6 and TNF levels were increased at 90 minutes and sustained elevated even after 240 minutes. In groups 3 and 4, IL-6 and TNF levels were significantly lower at 90, 180 and 240 minutes compared to group 2. At 180 minutes, TSA levels in groups 2, 3, 4 and 5 were significantly different from baseline and 90 minute levels. At this time point, TSA levels of group 2 and 3 were significantly higher compared to group 4 and 5. Conclusion: In this acute lung injury model induced by I/R of the lower limbs, pretreatment with pentoxifylline, iloprost and cilostazol significantly attenuated proinflammatory activities and parenchymal lung damage.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2014.8304en_US
dc.identifier.endpage144en_US
dc.identifier.issn1301-5680
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84897727840en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage138en_US
dc.identifier.urihttps://dx.doi.org/10.5606/tgkdc.dergisi.2014.8304
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8442
dc.identifier.volume22en_US
dc.identifier.wosWOS:000330199000023en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIKen_US
dc.relation.ispartofTURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCilostazolen_US
dc.subjectiloprosten_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjectlung injuryen_US
dc.subjectpentoxifyllineen_US
dc.titleThe proinflammatory cytokine-mediated protective effects of pentoxifylline, iloprost, and cilostazol on a mitigating lung injury induced by lower limb ischemia and reperfusion in ratsen_US
dc.typeArticleen_US

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