Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis

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dc.authoridKoyluoglu, Gokhan -- 0000-0002-1140-169X; Altun, Ahmet -- 0000-0003-2056-8683en_US
dc.contributor.authorKoyluogu, Gokhan
dc.contributor.authorBageivan, Ihsan
dc.contributor.authorKaradas, Baris
dc.contributor.authorGuney, Cengiz
dc.contributor.authorDurmus, Nedim
dc.contributor.authorAltun, Ahmet
dc.contributor.authorKaya, Tijen
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:15:32Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:15:32Z
dc.date.issued2008
dc.department[Koyluogu, Gokhan -- Guney, Cengiz] Cumhuriyet Univ, Fac Med, Dept Pediat Surg, TR-58140 Sivas, Turkey -- [Bageivan, Ihsan -- Durmus, Nedim -- Altun, Ahmet -- Kaya, Tijen] Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- [Karadas, Baris] Ataturk Training & Res Hosp, Dept Pharmacol, Izmir, Turkeyen_US
dc.description.abstractThe aim of this study was to investigate the effects of peritonitis on spontaneous contractions of ileum and jejunum smooth muscles isolated from rats. Peritonitis was induced by cecal ligation and puncture in 8 rats. Another group of 8 rats underwent a sham operation and acted as controls. Twenty-four hours after the operation, the rats were killed, and their ileum and jejunum smooth muscles were excised and placed in circular muscle direction in a 10 ml organ bath. Changes in the amplitude and frequency of spontaneous contractions were analyzed before and after the addition of different antagonists. Peritonitis induced the decrease in the amplitude and frequency of spontaneous contractions in ileum and jejunum smooth muscles. In control groups, both ileum and jejunum, the amplitude and frequency of spontaneous contractions were significantly elevated in the presence of N-G-nitro-L-arginine (L-NNA) and indomethacin. In peritonitis groups, both ileum and jejunum, the amplitude and frequency of spontaneous contractions were significantly enhanced in the presence Of L-NNA, aminoguanidine, indomethacin and celecoxib compared to control values. In conclusion, peritonitis induces the decrease in the amplitude and frequency of spontaneous contractions of ileum and jejunum that can be attributed to the rise of nitric oxide synthase and cyclooxygenase isoforms levels. (c) 2007 Elsevier B.V All rights reserved.en_US
dc.identifier.doi10.1016/j.ejphar.2007.10.064en_US
dc.identifier.endpage255en_US
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.issue01.Feben_US
dc.identifier.pmid18029280en_US
dc.identifier.scopus2-s2.0-37749004049en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage250en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejphar.2007.10.064
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10426
dc.identifier.volume580en_US
dc.identifier.wosWOS:000252983100031en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofEUROPEAN JOURNAL OF PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperitonitisen_US
dc.subjectileumen_US
dc.subjectjejunumen_US
dc.subjectspontaneous contractionen_US
dc.subjectNOSen_US
dc.subjectCOXen_US
dc.titleAlterations in spontaneous contractions of rat ileum and jejunum after peritonitisen_US
dc.typeArticleen_US

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