Co and Zn Metal Phthalocyanines with Bulky Substituents: Anticancer, Antibacterial Activities and Their Inhibitory Effects on Some Metabolic Enzymes with Molecular Docking Studies

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dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridTUZUN, BURAK/0000-0002-0420-2043
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authoridBursal, Ercan/0000-0001-7289-4507
dc.contributor.authorTurkan, Fikret
dc.contributor.authorTaslimi, Parham
dc.contributor.authorCabir, Beyza
dc.contributor.authorAgirtas, Mehmet Salih
dc.contributor.authorErden, Yavuz
dc.contributor.authorCelebioglu, Hasan Ufuk
dc.contributor.authorTuzun, Burak
dc.date.accessioned2024-10-26T18:11:12Z
dc.date.available2024-10-26T18:11:12Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study, we reported the synthesis of new cobalt and zinc phthalocyanine compounds with ((ethylenediamine-N,N',N'-triacetic acid-N-2-ethyl)oxy) (ETAEO) substituted groups. Characterization studies and anticancer properties of both synthesized compounds were determined as well. The inhibitory effects of these complexes on some metabolic enzymes were examined and it was observed that the enzymes inhibited by complex molecules at the micromolar levels. In addition, the active sites of the enzymes were determined by molecular modeling programme for screening the enzyme-inhibitor interactions. The molecular docking method was used to calculate the interactions of molecules with enzymes. Also, human prostate and breast cancer cell lines (PC-3 and MCF-7) were used to determine the anticancer properties of the complexes. All doses of the tetrakis (ETAEO) phthalocyaninato Cobalt II (1) did not show any significant changes in PC-3 cell viability, but significantly reduced in MCF-7 cell viability. Similarly, all doses of the tetrakis (ETAEO) phthalocyaninato zinc II (2) significantly reduced MCF-7 cell viability compared to the control and solvent control groups. According to the enzyme inhibition studies, both complexes showed the best inhibition effects for alpha-Glycosidase enzyme with 125.85 +/- 30.35 mu M and 165.30 +/- 27.18 mu M Ki values.
dc.identifier.doi10.1080/10406638.2021.1893194
dc.identifier.endpage4486
dc.identifier.issn1040-6638
dc.identifier.issn1563-5333
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85102891086
dc.identifier.scopusqualityQ3
dc.identifier.startpage4475
dc.identifier.urihttps://doi.org/10.1080/10406638.2021.1893194
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30567
dc.identifier.volume42
dc.identifier.wosWOS:000630387800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPolycyclic Aromatic Compounds
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPhthalocyanine
dc.subjectantibacterial
dc.subjectanticancer
dc.subjectenzyme inhibition
dc.subjectmolecular docking
dc.titleCo and Zn Metal Phthalocyanines with Bulky Substituents: Anticancer, Antibacterial Activities and Their Inhibitory Effects on Some Metabolic Enzymes with Molecular Docking Studies
dc.typeArticle

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