Determination of mechanical properties of polymeric microspheres used in controlled drug delivery systems by nanoindentation

Basit Öğe Kaydı
dc.authoridSARACOGLU KAYA, Berna -- 0000-0003-4706-5146en_US
dc.contributor.authorKucukoflaz, Merve
dc.contributor.authorKaya, Berna Saracoglu
dc.contributor.authorCaglayan, Mustafa Oguzhan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:37:20Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:37:20Z
dc.date.issued2019
dc.department[Kucukoflaz, Merve -- Caglayan, Mustafa Oguzhan] Cumhuriyet Univ, Nanotechnol Dept, Sivas, Turkey -- [Kaya, Berna Saracoglu] Cumhuriyet Univ, Chem Engn Dept, Sivas, Turkeyen_US
dc.description.abstractIn this study, we synthesized poly (vinyl acetate-co-divinyl benzene) microspheres with various monomer/cross-linker contents for oral/topical sustained drug release applications and determined the micromechanical properties by nanoindentation. Compression elastic moduli of materials were calculated by using the limited depth of indentation according to Hertz elastic deformation model and presented as the histogram of multiple data. In terms of drug release practices, poly (VAc-co-DVB) microspheres with a high DVB content, especially in topical applications, are expected to carry drugs under mechanical stresses of less than 1.0 GPa. [GRAPHICS] .en_US
dc.identifier.doi10.1080/03602559.2018.1520252en_US
dc.identifier.endpage775en_US
dc.identifier.issn2574-0881
dc.identifier.issn2574-089X
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85074814906en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage765en_US
dc.identifier.urihttps://dx.doi.org/10.1080/03602559.2018.1520252
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6029
dc.identifier.volume58en_US
dc.identifier.wosWOS:000463821100006en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofPOLYMER-PLASTICS TECHNOLOGY AND MATERIALSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectControlled drug releaseen_US
dc.subjectdrug delivery systemsen_US
dc.subjectpolymeric microsphereen_US
dc.subjectnanoindentationen_US
dc.subjectnanomechanical propertiesen_US
dc.titleDetermination of mechanical properties of polymeric microspheres used in controlled drug delivery systems by nanoindentationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu